An observational study in Bariatric Surgery, Bone Health and Obesity, Morbid, sponsored by CHU de Quebec-Universite Laval. Recruiting at 3 sites in Canada. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-10.
Sponsored by CHU de Quebec-Universite Laval · Observational
Among 32 studies in Obesity, Morbid with a site in Canada — 7 open to participants now, 10 under way, none of them phase 3. Obesity, Morbid · Canada.
Among the 32 studies in Obesity, Morbid with a site in Canada, this one is the 8th largest by planned enrollment of the 10 observational ones that give a count, is one of 3 that started in 2018, is one of 10 observational ones, and was the 18th registered.
941 studies on the registry are indexed under Obesity, Morbid; 163 are open to participants now.
Browse Obesity, Morbid studies →7 of the 32 studies in Obesity, Morbid with a site in Canada are open now. Recruiting first, the newest first:
Laval University · Sites in Canada
Laval University · Sites in Canada
CHU de Quebec-Universite Laval · Sites in Canada
Nova Scotia Health Authority · Sites in Canada
Laval University · Sites in Canada
A study can be open while its sites in Canada have not opened yet or have stopped. Only those recruiting at a site in Canada →
Of the 109 Obesity, Morbid studies recruiting now, 21 (19%) set no upper age limit and 83 (76%) stop at 75 or younger; 8 take children under 18; 9 take healthy volunteers.
This study: 18 Years to 60 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
32 studies; the count open now beside each. This study's row is marked.
First in 2006; this study’s year is marked. 3 started in 2018.
This study's planned enrollment of 100 is above the median of 80 across 311 observational studies indexed under Obesity, Morbid.
Median enrollment 57 across the 22 interventional studies, 145 across the 10 observational. Of the 18 that completed or were terminated, 7 (39%) have results posted.
This tab as a report to print or save as PDF → With an account.
1 of 32 have an industry lead sponsor. The 10 most frequent:
CHU de Quebec-Universite Laval is the lead sponsor of 137 studies on the registry; 27 are open to participants now.
CHU de Quebec-Universite Laval has 2 studies filed under Obesity, Morbid — fewer than ten, so there is no comparison to draw.
3 of the studies in Obesity, Morbid with a site in Canada that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05242835Laval UniversityManagement of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery | 2027-01 |
| NCT05120492Nova Scotia Health AuthorityOptimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial | 2027-07 |
| NCT06002906University Health Network, TorontoThe Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery. | 2027-07-03 |
Among the 32 studies in Obesity, Morbid with a site in Canada, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population. Bariatric surgery is gaining in popularity in people with type 2 diabetes and may impact bone health. Objectives: To evaluate the impact of the most popular bariatric procedure worldwide (sleeve gastrectomy (SG)) on vBMD by QCT in patients with type 2 diabetes; Secondary aims: (1) to identify the determinants of vBMD after bariatric surgery in patients with type 2 diabetes; (2) to compare vBMD and its potential determinants after bariatric surgery with obese controls without diabetes as well as with controls without obesity and normoglycemia.
This is a multicentre, prospective and observational study comprising a bariatric group with or without diabetes undergoing SG (n=70) and one control group (n=30).
Outcome measures are assessed before and at 4 months, 8 months, one year and 3 years after surgery in the bariatric groups and at a single visit for the control group.
Bariatric groups will include adult men and women with or without type 2 diabetes and obesity undergoing sleeve gastrectomy and followed at 0, 4 months, 8 months, 1 year and 3 years after surgery, and the control group will consist of 30 overweight individuals (10 men, 10 premenopausal women, 10 menopausal women) and without diabetes or prediabetes and assessed at a single visit.
This is a multicentre, prospective and observational study comprising a bariatric group with or without diabetes undergoing SG (n=70) and one control group (n=30).
Bariatric groups will include adult men and women with or without type 2 diabetes and obesity undergoing sleeve gastrectomy and followed at 0, 4 months, 8 months, 1 year and 3 years after surgery, and the control group will consist of 30 overweight individuals (10 men, 10 premenopausal women, 10 menopausal women) and without diabetes or prediabetes and assessed at a single visit.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Control group: Same criteria plus: >5% change in weight in the last 3 months; pregnancy or lactation in the last year.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
How quickly the kidneys clear creatinine, a waste product, from the blood. A study may estimate it from a blood test with age, weight and sex (often by the Cockcroft–Gault formula), or measure it using blood and urine collected over a set time. Given in mL/min; higher is better.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Creatinine clearance (CrCl)
How quickly the kidneys clear creatinine, a waste product, from the blood. A study may estimate it from a blood test with age, weight and sex (often by the Cockcroft–Gault formula), or measure it using blood and urine collected over a set time. Given in mL/min; higher is better.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
70 Men and women with or without type 2 diabetes and obesity undergoing sleeve gastrectomy
Procedure: Bariatric surgery
30 Men and women who are overweight (without obesity) and without diabetes
Sleeve gastrectomy
Change in volumetric bone mineral density (vBMD) at lumbar spine, hip, tibia and radius
assessed by quantitative computed tomography (QCT)
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in areal bone mineral density at lumbar spine, hip and radius
assessed by dual-energy X-ray absorptiometry (DXA)
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in N-terminal propeptide of type 1 procollagen (P1NP)
serum bone formation marker
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in osteocalcin (total, gamma-carboxylated and and under-carboxylated)
serum bone formation marker
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in bone alkaline phosphatase
serum bone formation marker
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in C-telopeptide
serum bone resorption marker
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in fasting glucose
diabetes control
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in HbA1c
diabetes control
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in fasting insulin
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in serum 25-hydroxyvitamin D
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in parathormone (PTH)
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in estradiol and estrone
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in insulin like growth factor (IGF)-1
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in sclerostin
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in adiponectin
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in leptin
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in peptide YY (PYY)
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in ghrelin
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in oxidative stress markers
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in serum advanced glycation end products (AGEs)
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in Free fatty acids (FFA)
hormones involved in bone metabolism
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in fat and lean mass
body composition assessed by bioimpedance and by DXA
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in visceral and subcutaneous adipose tissue
body composition assessed by computed tomography (CT)
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in muscle mass and fat content at mid-femur
assessed by computed tomography (CT)
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in upper extremity muscle strength
assessed by hand grip strength
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in lower extremity muscle strength
assessed by knee extensor strength
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in muscle function
assessed by timed up and go test
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in physical capacity
assessed by 6-minute walk test
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in balance
assessed by Fullerton Advanced Balance (FAB) Scale
Time frame: before and 1 year after bariatric surgery
Change in sociodemographic factors
questionnaire
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in nutrition
3 web-based 24-h recalls
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in self-reported physical activity level
by questionnaire
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Change in measured physical activity level
by accelerometer
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in gut microbiota
stool sample
Time frame: before, 1 year after and 3 years after bariatric surgery
Change in cutaneous Advanced glycation end products (AGEs)
skin autofluorescence
Time frame: before, 4 months after, 8 months after, 1 year after and 3 years after bariatric surgery
Bone microarchitecture and metabolism
by iliac crest bone biopsy after tetracycline labelling using standard histomorphometry
Time frame: during surgery
Prevalence and incidence of vertebral fractures (by a CT scout of T4-L5)
Using the algorithm-based qualitative method (ABQ) and the Genant method
Time frame: before, 1 year after and 3 years after bariatric surgery
Prevalence and incidence of falls
by questionnaire
Time frame: before, 1 year after and 3 years after bariatric surgery
Prevalence and incidence of non-vertebral fractures
by questionnaire (self-reported)
Time frame: before, 1 year after and 3 years after bariatric surgery
Not enrolling at this site.
Not enrolling at this site.
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2018 (actual). Primary completion is estimated for Dec 2025, 92 months after the start.
Of 137 non-industry observational studies under Obesity, Morbid, half reached primary completion within 46 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 132. This study's planned 92 months is above that.
Counting every sponsor, half of 138 studies reached it within 46 months; a quarter within 16 and three quarters within 132.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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CHU de Quebec-Universite Laval →