A Phase 2/3 interventional study of fMRI and Indirect calorimetry in Obesity, sponsored by Rennes University Hospital. Completed at 1 site in France. Open to female participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2023-08-01.
Sponsored by Rennes University Hospital · Phase 2/3, Interventional, and Other
Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making
Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.
Exclusion Criteria:
Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months
Device: fMRI · Device: Indirect calorimetry · Device: Bioimpedance · Biological: Lipid profile, glucose, HBA1c, metabolomic analysis · Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)
Patients (20) will be selected from the Yale Food Addiction Scale (YFAS): a validated screening of FA questionnaire. Three clinical visits will be realized in less than two months
Device: fMRI · Device: Indirect calorimetry · Device: Bioimpedance · Biological: Lipid profile, glucose, HBA1c, metabolomic analysis · Behavioral: YFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)
Brain MRI
Resting energy expenditure
Measurement of body composition
Blood sample
Questionnaires to characterize eating habits and depression
Significant change in brain activity of the prefrontal cortex (area involved in the inhibitory control of food intake) measured by modification of BOLD (Blood-Oxygen-Level-Dependent) signal in fMRI during a cognitive task based on food choice making
Time frame: Month 2
Plan to share: No
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Rennes University Hospital