An interventional study of Diet Zinc in Inflammation, Oxidative Stress and Dyslipidemias, sponsored by UCSF Benioff Children's Hospital Oakland. Completed at 1 site in United States. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-14.
Sponsored by UCSF Benioff Children's Hospital Oakland · Not applicable, Interventional, and Basic science
The purpose of this study is to determine the effect of different dietary zinc intakes on fatty acid metabolism and other zinc biomarkers
This research is a dietary intervention study designed to evaluate the effect of progressive changes in Zn intake on fatty acid metabolism and to correlate those changes with biomarkers of dyslipidemia and insulin resistance. The main objective is to validate plasma fatty acid metabolism as a biomarker of inadequate Zn intake in subjects consuming identical diets with specific Zn content. The relative sensitivity of some fatty acid enzyme activities will also be compared to the DNA strand breaks. In addition to the primary objectives, correlations in enzyme activity with changes in fat metabolism, namely circulating triglyceride and cholesterol, will be determined. This will enable the determination of the effect of a low Zn intake on various aspects of dyslipidemia. Similar correlational analyses will be performed with clinical measures of inflammation and insulin resistance.
Exclusion Criteria:
3 dietary zinc levels: 6 mg/d, 11 mg/d and 25 mg supplemental zinc/d
Other: Diet Zinc
4 mg zinc from zinc biofortified wheat, was added to a controlled diet; 25 mg supplemental zinc was given during the final recovery period
Lipidomics changes
Change in Fatty acid metabolism
Time frame: Day 0, day 15, day 57 and day 71
DNA strand breaks changes
change in COMET assay olive-tail moments
Time frame: Day 0, day 15, day 57 and day 71
Polar Metabolomics changes
Change in Polar Metabolomics
Time frame: Day 0, day 15, day 57 and day 71
Mineral analysis changes
Changes in Plasma Zinc
Time frame: Day 0, day 15, day 57 and day 71
Body weight changes
changes in Body weight
Time frame: Day 0, day 15, day 57 and day 71
Fat allocation changes
Changes in waist circumference
Time frame: Day 0, day 15, day 57 and day 71
Plan to share: No
This study is completed, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.
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UCSF Benioff Children's Hospital Oakland