An interventional study of High Intensity Interval Training and Moderate Continuous Exercise Training in Type 1 Diabetes Mellitus and Endothelial Dysfunction, sponsored by Hospital de Clinicas de Porto Alegre. Completed at 1 site in Brazil. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2018-03-05.
Sponsored by Hospital de Clinicas de Porto Alegre · Not applicable, Interventional, and Supportive care
Among 48 studies in Diabetes Mellitus, Type 1 with a site in Brazil — 6 open to participants now, 10 under way, 5 of them phase 3. Diabetes Mellitus, Type 1 · Brazil.
Among the 48 studies in Diabetes Mellitus, Type 1 with a site in Brazil, this one is the 30th largest by enrollment of the 43 interventional ones that give a count, is one of 2 that started in 2015, is one of 13 with no phase, and was the 32nd registered.
3,754 studies on the registry are indexed under Diabetes Mellitus, Type 1; 600 are open to participants now.
Browse Diabetes Mellitus, Type 1 studies →6 of the 48 studies in Diabetes Mellitus, Type 1 with a site in Brazil are open now. Recruiting first, the newest first:
Eli Lilly and Company · Sites in Brazil, United States, Australia and 17 more countries
Eli Lilly and Company · Sites in Brazil, United States, Australia and 16 more countries
Sanofi · Sites in Brazil, United States, Argentina and 17 more countries
University of Sao Paulo · Sites in Brazil
Glucotrack · Sites in Brazil
A study can be open while its sites in Brazil have not opened yet or have stopped. Only those recruiting at a site in Brazil →
Of the 411 Diabetes Mellitus, Type 1 studies recruiting now, 128 (31%) set no upper age limit and 257 (63%) stop at 75 or younger; 184 take children under 18; 64 take healthy volunteers.
This study: 18 Years to 40 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
48 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 3 · Phase 3 23 · Phase 4 4
First in 2002; this study’s year is marked. 2 started in 2015.
This study's enrollment of 36 is close to the median of 40 across 2,820 interventional studies indexed under Diabetes Mellitus, Type 1.
Median enrollment 150 across the 43 interventional studies, 80 across the 5 observational. Of the 32 that completed or were terminated, 15 (47%) have results posted.
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28 of 48 have an industry lead sponsor. The 10 most frequent:
Hospital de Clinicas de Porto Alegre is the lead sponsor of 456 studies on the registry; 61 are open to participants now.
Hospital de Clinicas de Porto Alegre has 3 studies filed under Diabetes Mellitus, Type 1 — fewer than ten, so there is no comparison to draw.
4 of the studies in Diabetes Mellitus, Type 1 with a site in Brazil that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06914895Phase 3Eli Lilly and CompanyA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | 2026-11 |
| NCT06962280Phase 3Eli Lilly and CompanyA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight | 2026-11 |
| NCT06934707Hospital de Clinicas de Porto AlegreMeal Frequency and Glycemic Control in Individuals With Type 1 Diabetes | 2026-12-29 |
| NCT06812988SanofiTreatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule | 2027-04-29 |
Among the 48 studies in Diabetes Mellitus, Type 1 with a site in Brazil, from their registry updates:
Nothing recorded among them since 2026-09-25.
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To study the effect of 8 week high-intensity interval training (HIIT) compared with moderate intensity (MCT) interval training and sedentary patients(CON) with type 1 diabetes. Adult T1DM patients without known complications are randomised in blocks into these 3 groups according to their baseline flow mediated dilation (FMD). After 8 week exercise training, the main outcome, FMD, is re-evaluated. Additional variables such as VO2 peak for cardiovascular fitness, oxidative stress and endothelial independent vasodilation to study vascular rigidity are also evaluated.
In a randomized controlled open trial, 36 adult type 1 diabetes mellitus (T1DM) patients without known complications were randomized into 3 groups: HIIT n=12; MCT n=12 and a sedentary control group (CON) n=12. Total sample size was calculated to a power of 80% alha 0.05 and a difference in mean FMD of 2%. Before randomisation, flow mediated dilation (FMD) and maximal exercise capacity (VO2 peak)is determined. Block Randomisation based on FMD rank values are done to equalize baseline FMD. Exercise sessions are performed in cycle ergometers during 40 minutes, 3 times a week, along 8 weeks. HIIT protocol, intensity vary from 50 to 85% of the maximum heart rate (HRmax), while in MCT, HR remained stable at 50% HRmax. Endothelial function was measured by flow mediated dilation (FMD) for endothelium-dependent vasodilation (EDVD) and smooth-muscle function was measured by nitroglycerine mediated dilation (endothelium independent vascular dilation) - (EIVD). Peak oxygen consumption (VO2peak) and oxidative stress markers were determined before and after the training period. ED was defined as an increase of less than 8% in vascular diameter after cuff release.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
T1DM
Exclusion Criteria:
High Intensity Interval Exercise Training in cycle ergometer 3 times a week for 8 weeks
Behavioral: High Intensity Interval Training
Moderate Continuous Interval Training
Behavioral: Moderate Continuous Exercise Training
Sedentary Type 1 Diabetes Controls.
Other: Non-exercise
High Intensity Interval Exercise Training in cycle ergometer, exercising at 80% of maximal capacity during one minute alternated with exercise at 50% of maximal capacity during 4 minutes intervals, for a total of 30 minutes. Three times a week for 8 weeks
Moderate Continuous Exercise Training 3 times a week for 8 weeks at 50% of maximal capacity
Conventional care for sedentary Type 1 Diabetes Controls. No intervention.
Endothelial Dependent Mediated Vascular Dilation
Percent of change from baseline in flow mediated dilation measured through arterial ultrasound at right arm
Time frame: 8 weeks
Peak oxygen consumption
Percent of change in maximal oxygen capacity measured by in maximal oxygen consumption
Time frame: 8 weeks
Endothelial independent vascular dilation
Percent of change from baseline in nitrate mediated dilation measured through arterial ultrasound at right arm
Time frame: 8 weeks
Plan to share: No
Ran from Jan 2015 to primary completion in Jan 2016, 12 months.
Of 844 non-industry interventional studies with no phase under Diabetes Mellitus, Type 1, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 38. This study's 12 months is below that.
Counting every sponsor, half of 949 studies reached it within 18 months; a quarter within 9 and three quarters within 35.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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