CClinicalTrials.gg
CompletedNCT03450148Updated Jul 15, 2021

Aversive Therapy for Smoking Cessation

An interventional study of Pavlok wristband with electric stimulus and Pavlok wristband without electric stimulus in Smoking Cessation, sponsored by University of Alabama at Birmingham. Completed at 1 site in United States. Open to participants aged 19 Years to 99 Years. Per ClinicalTrials.gov, last updated 2021-07-15.

Sponsored by University of Alabama at Birmingham · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
48
Allocation
Randomized
Ages
19 Years to 99 Years
Sex
All
01

Study summary

The purpose of this research study is to test a new way to help people quit smoking. The PI will test acceptability and feasibility of a new device called Pavlok wearable wrist band. Participants will be smokers who are highly motivated to quit. Participants will be randomized into intervention and control groups.

Read the detailed description

The participants will be evaluated after 1 week and assessed for their ongoing participation and commitment to the study. Those still interested and eligible will be randomized to two groups described below and will continue the study for 3 more weeks. There will be follow up surveys at various time points while wearing the wristband (1 week, 2 week, 3 weeks) and a final survey at T=3 months.

The intervention group will continue to wear the wristband and the wristband will deliver a slight electric stimulus every time it is pressed.

The placebo group will wear continue to press the button on the wristband but it will not give a slight electric stimulus when pressed. Both groups will wear the device for a total of 4 weeks.

02

Conditions studied

  • Smoking Cessation

Keywords

  • aversive therapy
03

Who can participate

Ages eligible
19 Years to 99 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Current smoker (defined by the Center for Disease Control as an "adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes ". This will be determined based on participant baseline survey.
  • Interested in quitting (contemplation stage and beyond, as defined by serious consideration of quitting smoking in the next 30 days
  • Subject is equal to or greater than 19 years old
  • Considers themselves "tech savvy" (based on self reported 5 point likert scale)
  • Must have a smart phone with blue tooth capabilities
  • Willing to receive aversive therapy if assigned to this group.

Exclusion criteria

Exclusion Criteria:

  • Anyone with a diagnosed arrhythmia or with a pacemaker or with a phobia or history of psychosis.
  • Non-English speaking caregivers
  • Lives outside of contiguous United States
04

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
48 participants (actual)

Study arms

  • Experimental
    Pavlok wristband with electric stimulus

    Participants in intervention group will wear wristband and will get a slight electric stimulus when they press the device

    Other: Pavlok wristband with electric stimulus

  • Placebo comparator
    Pavlok wristband without electric stimulus

    Participants in control group will wear wristband and will not get a slight electric stimulus when they press the device

    Other: Pavlok wristband without electric stimulus

Interventions

  • OtherPavlok wristband with electric stimulus

    it is a device for various behavior modifications in the form of wristband which participants will wear on the wrist. Device has maximum voltage of 0-500 volts, delivers a electric stimulus for a maximum of 1 sec and average duration of 0.2 secs

  • OtherPavlok wristband without electric stimulus

    it is a device for various behavior modifications in the form of wristband which participants will wear on the wrist. Participants will not receive any electric stimulus since this feature will be turned off.

05

What researchers measure

Primary outcomes

  1. Participants acceptability: short customized survey

    Participants' acceptability/satisfaction will be assessed using a short customized survey. The survey will include 8 questions with options ranging from strongly agree to strongly disagree for five questions and ranging from satisfaction to dissatisfaction for the remainder 3 questions. Each question will be evaluated individually.

    Time frame: T=0 to 3 months

  2. Evaluate the dropout among participants

    Number of participants dropped out from time of randomization. Dropout is defined as missing two follow up assessments.

    Time frame: T=0 to 3 months

  3. Enrollment percentage of eligible participants

    PI will evaluate the percentage of participants that were enrolled after the 1 week run in period.

    Time frame: Baseline to T=0

  4. Percentage of time wristband worn by participants

    PI will evaluate the percentage of time the wristband is worn. Instructions will be given to wear the wristband all of the waking hours.

    Time frame: T=0 to one week

  5. Percentage of time wristband worn by participants

    PI will evaluate the percentage of time the wristband is worn. Instructions will be given to wear the wristband all of the waking hours.

    Time frame: from one week to two weeks

  6. Percentage of time wristband worn by participants

    PI will evaluate the percentage of time the wristband is worn. Instructions will be given to wear the wristband all of the waking hours.

    Time frame: from two week to three weeks

  7. Participants satisfaction: short customized survey

    Participants' acceptability/satisfaction will be assessed using a short customized survey. The survey will be a Likert scale and will include 2 questions with options ranging from satisfied to dissatisfied (with 1 indicating satisfaction and 5 indicating dissatisfaction). One other question is a likert scale with options ranging from 1-3 with 1 indicating the device was very useful and 3 indicating the device was not at all useful. A higher score indicates a worse outcome (less satisfaction with the device). Each question will be evaluated individually.

    Time frame: T=0 to 3 months

Secondary outcomes

  1. Percentage of participants that made a quit attempt

    PI will evaluate the percentage of participants that made a quit attempt as defined by absence of smoking for more than 24 hours in the previous seven days. This will be assessed through the follow up survey given at various intervals.

    Time frame: From T=0 to one week

  2. Percentage of participants that made a quit attempt

    PI will evaluate the percentage of participants that made a quit attempt as defined by absence of smoking for more than 24 hours in the previous seven days. This will be assessed through the follow up survey given at various intervals.

    Time frame: From T=1 week to 2 weeks

  3. Percentage of participants that made a quit attempt

    PI will evaluate the percentage of participants that made a quit attempt as defined by absence of smoking for more than 24 hours in the previous seven days. This will be assessed through the follow up survey given at various intervals.

    Time frame: From T= 2 weeks to 3 weeks

  4. Average Degree of smoking reduction

    PI will evaluate the average percentage of smoking reduction. This will be quantified by the average number of cigarettes smoked at baseline compared to the average number of cigarettes smoked at 3 months. This will be assessed via the "Follow survey".

    Time frame: From baseline to 3 months

  5. Percentage of participants who had cessation of smoking.

    P will evaluate the percentage of participants who had cessation of smoking, as defined by the absence of smoking in the previous 30 days. This will be evaluated by the "Three month Questionnaire"

    Time frame: T=0 to T= 3 weeks

  6. Before and after smoking self-efficacy score

    The PI will evaluate the self-efficacy of the participant as evaluated by the "Baseline Smoking self-efficacy scale Short form". There are 9 questions which will assess the confidence of the participant to not smoke.The investigators will use Likert scale for each question which assesses the participants confidence to "not smoke" in various circumstances. The answers range from 1 to 5 with 1 indicating "not at all confident" and 5 indicating "extremely confident". The overall score for each participant will be calculated by sum of scores from all items. This score for individual subscales will be calculated by sum item scores so that the total score will range from 9 to 45, with a lower score indicating a worse outcome i.e. less confidence to not smoke).

    Time frame: Baseline to 3 months

  7. Stage of change

    The investigators will use Likert scale for each question to evaluate the motivation to change. A score of 1 indicates that the participant has no intention to quit smoking and the score of 5 indicates that the participant is highly motivated. Evaluate the initial stage of change of the participant as judged by "Screening Questionnaire, Stage of Change". There is only 1 question.

    Time frame: From baseline until 3 months

06

Study locations

1 site
  • Univeristy of Alabama at Birmingham
    Birmingham, Alabama 35294, United States
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03450148
Lead sponsor
University of Alabama at Birmingham
Responsible party
Nipam Shah, MD (Principal Investigator, University of Alabama at Birmingham) — Principal investigator
First posted
Mar 1, 2018
Start date
Jul 20, 2018
Primary completion
Nov 30, 2020
Completion
May 1, 2021
Last update
Jul 15, 2021

Study contacts

Laura Rochford, MD
principal investigator · University of Alabama at Birmingham

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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