ClinicalTrials.gg
TerminatedNCT03432000TOCASUpdated Aug 1, 2025

Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia

An interventional study of Performances of patients and controls on temporal task in Schizophrenia, sponsored by Hôpital le Vinatier. Terminated at 1 site in France. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-01.

Sponsored by Hôpital le Vinatier · Not applicable, Interventional, and Other

Why this study was terminated
Investigator departure

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Phase
Not applicable
Study type
Interventional
Enrollment
52
Allocation
Non-randomized
Ages
18 Years to 45 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 32 studies in Schizophrenia by Hôpital le Vinatier — 6 open to participants now, 6 under way, none of them phase 3. Schizophrenia · Hôpital le Vinatier.

Enrollment
18th of 31
52 · median 60
Started
2018
with 2 others
No phase
31 of 32
6 open now
Registered
20th of 32
by date

Among the 32 studies in Schizophrenia by Hôpital le Vinatier, this one is the 18th largest by enrollment of the 31 interventional ones that give a count, is one of 3 that started in 2018, is one of 31 with no phase, and was the 20th registered.

Schizophrenia

3,567 studies on the registry are indexed under Schizophrenia; 493 are open to participants now.

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Open to participants now

6 of the 32 studies in Schizophrenia by Hôpital le Vinatier are open now, in 1 country. Recruiting first, the newest first:

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By country, each count listing its studies:

All 6 open studies →

Where they have run

Who these studies take

Of the 332 Schizophrenia studies recruiting now, 63 (19%) set no upper age limit and 258 (78%) stop at 75 or younger; 42 take children under 18; 83 take healthy volunteers.

This study: 18 Years to 45 Years · all sexes · healthy volunteers too.

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02

Study summary

People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

Read the detailed description

The objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality.

To carry out this work, the investigators will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

03

Conditions studied

  • Schizophrenia

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04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Subjects with schizophrenia:

  • Age from 18 to 45 years
  • Diagnosis of schizophrenia according to DSM V criteria
  • French mother tongue
  • Psychotropic treatment unchanged during the month preceding the inclusion
  • Stable symptomatology
  • Normal or corrected visual acuity (> 0.8 at Snellen scale) and normal color vision
  • Patients who gave to participate in the study

Control subjects (healthy volunteers):

  • Age from 18 to 45 years
  • Absence of neurological and psychiatric disorders
  • French mother tongue

Exclusion criteria

Exclusion Criteria:

  • Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
  • Neurological disorders of vascular, infectious or neurodegenerative origin
  • Taking somatic drugs with a cerebral or mental impact (eg )
  • Disabling sensory disturbances, and in particular visual acuity
  • Participation in a Neuro Cognitive Remediation Program
  • Schizophrenia resistant to neuroleptic treatments
  • Persons protected by law (pregnant women, minors, major under guardianship ...)
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

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Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

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05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
52 participants (actual)

Study arms

  • Experimental
    subjects with schizophrenia

    Performances on temporal task Subjective alterations of time perception in patients with an adapted scale (EAWE) Global symptomatology with PANSS (positive and negative symptom scale)

    Other: Performances of patients and controls on temporal task

  • Sham comparator
    healthy subjects

    Evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm (Michotte paradigm) and to compare performance between healthy subjects and controls Investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time (EAWE scale) in the group of subjects with schizophrenia

    Other: Performances of patients and controls on temporal task

Interventions

  • OtherPerformances of patients and controls on temporal task

    To carry out this work, we will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

06

What researchers measure

Primary outcomes

  1. Comparison of the scores obtained by subjects with schizophrenia vs. the controls for the causal tasks, according to the delays between stimuli (stopping the moving launcher and appearance of the static object).

    Michotte paradigm: evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm

    Time frame: eight months

Secondary outcomes

  1. Comparisons of the scores obtained on the Time Experiment Rating Examination of Anomalous World Experience Scale (EAWE).

    Examination of Anomalous World Experience (EAWE ) scale:investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time The E.A.W.E. consists of 6 dimensions (relation to space / relation to time / relation to others / language / atmospheric experience / existential orientation).The second domain only will be explored in our study Each item is both detailed, on a scale of 0 to 2 (0 for absent, 1 for present but with doubt, 2 for present, no doubt). The overall score of the sub-time scale thus ranges between 0 and 78.

    Time frame: eight months

07

Study locations

1 site
  • Vial Veronique
    Bron, Auvergne-Rhône-Alpes 69678, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Feb 2018 to primary completion in May 2022, 51 months.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 7, 2018
First posted
Feb 13, 2018
StartActual
Feb 1, 2018
Primary completionActual
May 24, 2022
CompletionActual
May 24, 2022
Last update
Aug 1, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 1, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03432000
Responsible party
Sponsor
First posted
Feb 13, 2018
Start date
Feb 1, 2018
Primary completion
May 24, 2022
Completion
May 24, 2022
Last update
Aug 1, 2025

Study contacts

MARTIN BRICE
principal investigator · CH LE VINATIER

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.

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