An observational study in Pre B ALL and Regulatory T Cell, sponsored by Ankara Children's Health and Diseases Hematology and Oncology Training and Research Hospital. Status unknown. Open to participants aged 1 Year to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-29.
Sponsored by Ankara Children's Health and Diseases Hematology and Oncology Training and Research Hospital · Observational
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The investigators aimed to study the effect of chemotherapy on regulatory T cells (Tregs) in children with precursor B (PreB) acute lymphoblastic leukemia (ALL) at 15 and 33 days of malignity directed therapy. The investigators will analyze peripheral and bone marrow blood samples of the participants, obtained at diagnosis, 15 and 33 days of treatment, about Treg / non Treg cells and interleukin (IL)-2, IL-6, IL-10, and transforming growth factor (TGF) beta levels. By this means, investigators will search response to chemotherapy. Also, investigators will analyze correlation between Treg population-Treg related cytokines with demographic, clinical and laboratory findings of the participants with ALL at these certain time points. Additionally, the investigators will compare Treg population and minimal residual disease at 15-33 days of malignity directed therapy. Also investigators will compare these Treg-Treg related cytokines obtained from the participants with ALL and a healthy children control group whom are voluntary donors for bone marrow transplantation.
38 studies on the registry are indexed under Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; 16 are open to participants now.
Browse Precursor B-Cell Lymphoblastic Leukemia-Lymphoma studies →Ankara Children's Health and Diseases Hematology and Oncology Training and Research Hospital is the lead sponsor of 3 studies on the registry; none are open to participants now.
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The patients diagnosed with PreB ALL in a hematology clinic. Healthy children whom are volunraty bone marrow donors.
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Exclusion Criteria:
30 children with a recent diagnosis of PreB ALL
Diagnostic Test: Peripheral and bone marrow sampling
30 healthy children
Diagnostic Test: Peripheral and bone marrow sampling
We obtained blood from peripheral and bone marrow sampling. Then we analyze Treg population and Treg related cytokines with flow cytometry and ELISA methods.
Change from baseline in number of regulatory T-cells at 15 and 33th day during chemotherapy
The number of regulatory T-cells is measured in fresh peripheral and bone marrow blood by flow cytometry.
Time frame: Baseline, 15 and 33th day
Change from baseline IL-2, IL-6, IL-10, and TGF-beta levels at 15 and 33th day during chemotherapy
IL-2, IL-6, IL-10, and TGF-beta levels are measured in frozen peripheral and bone marrow blood by ELISA.
Time frame: Baseline, 15 and 33th day
No study locations are listed for this record.
Plan to share: Yes
No publications or documents are linked to this record.
Start is estimated for Jan 2018; primary completion for Jan 2019, 12 months later.
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This study is status unknown, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma →
Ankara Children's Health and Diseases Hematology and Oncology Training and Research Hospital