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CompletedNCT03412656CUFFUpdated Nov 20, 2020

Assessing Force Feedback With the SoftHand Pro

An interventional study of SoftHand Pro with CUFF force feedback device in Amputation, Traumatic and Limb Defect, sponsored by Kristin Zhao, PhD. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-11-20.

Sponsored by Kristin Zhao, PhD · Not applicable, Interventional, and Device feasibility

Phase
Not applicable
Study type
Interventional
Enrollment
27
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The trial is designed to test the effectiveness of a force-feedback cuff in combination with a myoelectric prosthesis in conveying information on grasp strength to the user, as well as the user's preference regarding the feature.

Read the detailed description

The human sensorimotor control system uses both feedforward planning and sensory feedback information, in order to actuate the musculoskeletal system and interact with the external environment, e.g. when modulating grip force for various object properties. As a result, lack of sensory input, as in the case of motor impairments or amputations, can dramatically affect activities of daily living (ADLs). The contribution of the proposed research will be to test the effectiveness of a novel, non-invasive prosthetic technology in delivering sensory information. The investigators' approach is "modality matching," in that it produces a sensation in the user similar to the type of information to be transmitted. Specifically, the approach will combine the Soft Hand Pro (SHP), an anthropomorphic, myoelectrically controlled prosthetic hand, with an upper limb force feedback device (CUFF) to provide patients with transradial amputations with grasp force (pressure) information.

02

Conditions studied

  • Amputation, Traumatic
  • Limb Defect

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Keywords

  • CUFF
  • Soft Hand Pro
  • SHP
  • SH Pro
  • SoftHand
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. age > 18 years.
  2. no prior experience with the CUFF device.
  3. history of elbow disarticulation, transradial, or transhumeral limb loss (non-control subjects only).

Exclusion criteria

Exclusion Criteria:

  1. amputation for less than 6 months
  2. clinical history of brachial plexopathy, cervical radiculopathy or polyneuropathy
  3. orthopedic, joint degeneration (i.e., arthritis, verified by x-ray) affecting the hand or cervical spine that severely limit upper limb function
  4. visual problems that would interfere with the grasp task
  5. co-existing central nervous system disease with symptoms that limit upper extremity function (e.g., multiple sclerosis, motor neuron disease, myasthenia gravis, Parkinson's disease, dystonia) revealed in medical history
  6. significant rigidity as assessed through range of motion testing
  7. active psychiatric illness
  8. significant cognitive impairments (a score \< 24 on the Mini-Mental State Examination)
  9. use of medications that might affect sensory and/or motor functions
  10. inability to effectively control myoelectrics for study purposes (control subjects only)
04

Study design

Phase
Not applicable
Primary purpose
Device feasibility
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
27 participants (actual)

Study arms

  • Experimental
    Patient

    Testing will include assessments of activities of daily living (ADLs) by a physical therapist, biomechanical measures of forces applied to objects and motion of the upper limb collected during commonly-performed tasks, and surveys assessing user preference regarding the force feedback feature, all while using the SoftHand Pro myoelectric lower arm prosthetic and the CUFF force feedback devices in tandem, utilizing the subjects' own prosthetic sockets. Grip force will be recorded using sensors attached to the CUFF device. During each session, videos will be obtained of the subjects performing tasks for kinematics analysis. The experimental sessions are organized into one to two sessions, comprising up to 16 hours, as determined by subject availability.

    Device: SoftHand Pro with CUFF force feedback device

  • Other
    Control

    Testing will include assessments of activities of daily living (ADLs) by a physical therapist, biomechanical measures of forces applied to objects and motion of the upper limb collected during commonly-performed tasks, and surveys assessing user preference regarding the force feedback feature, all while using the SoftHand Pro myoelectric lower arm prosthetic and the CUFF force feedback devices in tandem, utilizing an adapter simulating a prosthetic socket. Grip force will be recorded using sensors attached to the CUFF device. During each session, videos will be obtained of the subjects performing tasks for kinematics analysis. The experimental sessions are organized into one to two sessions, comprising up to 16 hours, as determined by subject availability.

    Device: SoftHand Pro with CUFF force feedback device

Interventions

  • DeviceSoftHand Pro with CUFF force feedback device

    Participants will complete various movement and activity of daily living (ADL) assessments to test the effectiveness of the CUFF device in combination with the Soft Hand Pro (SHP) in conveying haptic force feedback to patients with transradial limb loss, and to assess the extent to which the grip force feedback improves the embodiment of the prosthetic device.

    Also known as: SoftHand, SoftHand Pro, CUFF, SHpro

05

What researchers measure

Primary outcomes

  1. Conveyance of force feedback

    Assessments will measure the extent to which the CUFF device conveys haptic force feedback, when used in combination with the Soft Hand Pro.

    Time frame: 1 year

  2. Improvement to device embodiment through addition of grip force feedback

    Assessments will determine any improvement of device embodiment from the addition of grip force feedback to the Soft Hand Pro.

    Time frame: 1 year

06

Study locations

1 site
  • Mayo Clinic in Rochester
    Rochester, Minnesota 55905, United States
07

References and documents

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03412656
Lead sponsor
Kristin Zhao, PhD
Collaborators
Arizona State University, University of Pisa
Responsible party
Kristin Zhao, PhD (Principal Investigator, Mayo Clinic) — Sponsor-investigator
First posted
Jan 26, 2018
Start date
Oct 17, 2017
Primary completion
Jun 14, 2019
Completion
Jun 14, 2019
Last update
Nov 20, 2020

Study contacts

Kristin D. Zhao, Ph.D.
principal investigator · Mayo Clinic
Karen L. Andrews, M.D.
principal investigator · Mayo Clinic

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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