An observational study in Critical Illness and Fluid Responsiveness, sponsored by Uniwersytecki Szpital Kliniczny w Opolu. Withdrawn at 1 site in Poland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-01-23.
Sponsored by Uniwersytecki Szpital Kliniczny w Opolu · Observational
Passive leg raise (PLR) and fluid challenge are useful tools in assessing the fluid responsiveness. However, they require continuous monitoring of cardiac output, which is usually an invasive technique and in some cases not always available. Vascular ultrasound can be an alternative to cardiac output monitoring in a fluid status evaluation. The common carotid artery (CCA) is an easily accessible vessel. It has recently been noted that the diameter of this artery changes after an intravenous fluid bolus. It is possible that the change in the diameter of the common carotid artery during passive leg raise and fluid challenge can be a predictor of fluid responsiveness.
1,780 studies on the registry are indexed under Critical Illness; 442 are open to participants now.
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Mechanically ventilated patients admitted to critical care unit.
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Exclusion Criteria:
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A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Mechanically ventilated patients with acute circulatory failure, monitored with PiCCO method, who need fluid responsiveness assessment.
Diagnostic Test: fluid responsiveness assessment
During the procedure, the investigator will be imaging one of the carotid arteries with ultrasound. In expiratory phase, four sets of three video loops will be recorded: before and after PLR and then before and after fluid challenge. There also will be noted hemodynamic parameters measured with PiCCO monitor. The fluid challenge is defined as administration of 500ml of crystalloid in less than 10 minutes. Later, another investigator, who will be blinded to other data, will measure the maximal and minimal diameter of CCA in each loop. The measurements will be averaged and eventually two values (maximal an minimal) from each set will be obtained.
Also known as: passive leg raise, fluid challenge
Changes in the diameter of the common carotid artery
The diameter will be measured with ultrasound
Time frame: 1 minute after PLR test and 1 minute after fluid challenge
Evaluation the value of changes in the diameter of CCA as the predictor of fluid responsiveness.
The changes in the diameter of CCA will be compared with the changes in cardiac output measured with PiCCO method.
Time frame: 1 minute after PLR test and 1 minute after fluid challenge
Start is estimated for Jun 2019; primary completion for Oct 2020, 16 months later.
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This study is withdrawn, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Uniwersytecki Szpital Kliniczny w Opolu