An interventional study of Papain-based Chemo-mechanical caries removal agent and conventional rotary in Microbial Colonization, sponsored by Cairo University. Status unknown. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-01-31.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This study will be conducted to assess the efficacy of caries excavation using the papain-based chemo-mechanical method (Brix 3000) in comparison to conventional rotary tools in the reduction of the bacterial population in occlusal carious cavities
Twenty-three patients who will fulfill the inclusion criteria will be enrolled to the study. For every patient two contra-lateral class I carious molars will be selected, so the total number of included molars will be 46 molars. One contra-lateral molar will be randomly assigned to the chemo-mechanical (Brix 3000) caries removal technique and the other will be assigned to the conventional rotary one. From every molar two dentin specimens will be collected (baseline and after excavation) with a total of 92 samples
Exclusion Criteria:
papain chemomechenical caries removal agent (Birx 3000) and the exclusive Encapsulating Buffer Emulsifier (EBE) technology claim it has effective and selective proteolytic action
Drug: Papain-based Chemo-mechanical caries removal agent · Device: conventional rotary
conventional 330 bur
Drug: Papain-based Chemo-mechanical caries removal agent · Device: conventional rotary
Birx 3000 and the exclusive Encapsulating Buffer Emulsifier (EBE) technology claim it has effective and selective proteolytic action to remove collagen fiber in the carious tissue. It has an antibacterial and antifungal power, thus it has an antiseptic power at the tissue level .furthermore, this gel does not contain chloramines in its formula, which enhances its toxicological safety feature.
Also known as: Brix 3000
traditional rotary method
Also known as: round bur 330
bacterial count by Digital Colony Counter
The number of colonies will be expressed as colony-forming units (CFU/ml) compared before and after removal caries using brix 3000 or rotary method
Time frame: at the same visit (20 minutes)
No study locations are listed for this record.
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Cairo University