An interventional study of Propylene glycol and Glycerol intake and Mimicking intake in Metabolic Complication, sponsored by Université Libre de Bruxelles. Completed at 1 site in Belgium. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-17.
Sponsored by Université Libre de Bruxelles · Not applicable, Interventional, and Basic science
The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.
Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters.
Aims of this study : to test the following hypotheses :
To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.
Exclusion Criteria:
One gram intake of a Propylene glycol/Glycerol mix (50:50)
Other: Propylene glycol and Glycerol intake
Mimicking Propylene glycol/Glycerol intake with the device turns off
Device: Mimicking intake
Intake of 1 gram of propylene glycol/Glycerol mix (50:50). Blood sample before, 5 minutes and 20 minutes after intake.
Mimicking propylene glycol/glycerol intake with the device turns off. Blood sample before, 5 minutes and 20 minutes after intake.
Cardiorespiratory biological variables
Blood sample
Time frame: 5 minutes
Cardiorespiratory biological variables
Blood sample
Time frame: 20 minutes
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Plan to share: Undecided — Data will be shared upon reasonnable request
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Université Libre de Bruxelles