An interventional study of Measure of the minimal pain threshold with an algometer in Cardiac Surgery Subjects, sponsored by Université Libre de Bruxelles. Recruiting at 1 site in Belgium. Per ClinicalTrials.gov, last updated 2026-04-07.
Sponsored by Université Libre de Bruxelles · Not applicable, Interventional, and Treatment
The study aims to test the relationship between the preoperative pain threshold and the intraoperative need for opioids.
The objective of the study is to try to predict a patient's analgesic needs based on their objectively determined preoperative pain threshold.
The investigators will include patients scheduled for elective cardiovascular surgery.
The investigators will investigate the correlation between the preoperative pain threshold and intraoperative/postoperative opioid consumption in a highly standardized anesthesia setting.
Université Libre de Bruxelles is the lead sponsor of 45 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
In this arm, patients get a measure of their minimal pain threshold in the preoperative time, that is the only intervention they get in addition of the classic care support
Device: Measure of the minimal pain threshold with an algometer
The measure of the minimal pain threshold is taken the day before the cardiac surgery
Correlation between the pressure pain threshold and the consumption of opioid during and after the surgery
After the measure of the minimal pain threshold the day before the surgery, the investigators look at the quantity of Remifentanil which has been given to the patient during the surgery. Then they will look for a correlation
Time frame: From enrollment to the end of opioid administration during hospital stay, up to 6 days after the enrollment
Correlation between the pain threshold and the consumption of morphine during the post-operative time
After the measure of the minimal pain threshold the day before the surgery, the investigators look at the quantity of morphine which has been administrated by a PCA (Intravenous Patient-Controlled Analgesia (IV-PCA) with morphine) to the patient during the post-operative time. Then they are looking for a correlation.
Time frame: From enrollment to the end of opioid administration during hospital stay, up to 6 days after the enrollment
Plan to share: Yes — all IPD collected throughout the trial
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: Beginning 1 month after publication with no end date
Access criteria: reserchers working in the same area of research
No publications or documents are linked to this record.
Started Jan 2026 (actual). Primary completion is estimated for Dec 2026, 10 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Université Libre de Bruxelles