ClinicalTrials.gg
CompletedNCT03397303Nerf_SSIUpdated Sep 14, 2026

Quantification of Nerve Stiffness in Neuropathies

An interventional study of elastography measurements in Chronic Inflammatory Demyelinating Polyneuropathy, Charcot-Marie-Tooth Disease, Type IA and Anti-MAG Neuropathy, sponsored by Nantes University Hospital. Completed at 1 site in France. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by Nantes University Hospital · Not applicable, Interventional, and Basic science

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Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Non-randomized
Ages
18 Years to 65 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 38 studies in Polyradiculoneuropathy, Chronic Inflammatory Demyelinating with a site in France — 8 open to participants now, 10 under way, 7 of them phase 3. Polyradiculoneuropathy, Chronic Inflammatory Demyelinating · France.

Enrollment
20th of 29
36 · median 82
Started
2018
with 1 other
No phase
6 of 38
none open now
Registered
15th of 38
by date

Among the 38 studies in Polyradiculoneuropathy, Chronic Inflammatory Demyelinating with a site in France, this one is the 20th largest by enrollment of the 29 interventional ones that give a count, is one of 2 that started in 2018, is one of 6 with no phase, and was the 15th registered.

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

137 studies on the registry are indexed under Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; 51 are open to participants now.

Browse Polyradiculoneuropathy, Chronic Inflammatory Demyelinating studies →

Open to participants now

8 of the 38 studies in Polyradiculoneuropathy, Chronic Inflammatory Demyelinating with a site in France are open now. Recruiting first, the newest first:

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All 8 open studies →

A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →

Who these studies take

Of the 36 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating studies recruiting now, 24 (67%) set no upper age limit and 9 (25%) stop at 75 or younger; 4 take children under 18; 2 take healthy volunteers.

This study: 18 Years to 65 Years · all sexes · healthy volunteers too.

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02

Study summary

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

Read the detailed description

The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial.

Participants will be asked to remain relaxed during elastography measurements.

03

Conditions studied

  • Chronic Inflammatory Demyelinating Polyneuropathy
  • Charcot-Marie-Tooth Disease, Type IA
  • Anti-MAG Neuropathy
04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male or female aged 18 to 65
  • Having social insurance status
  • Having given
  • Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU)

Exclusion criteria

Exclusion Criteria:

For controls:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress
  • Diabetes, history of neuromuscular disease

For CIDP:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress
  • MRC score \< 3

For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    patients with peripheral neuropathies

    This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

    Other: elastography measurements

  • Other
    controls

    Other: elastography measurements

Interventions

  • Otherelastography measurements

    elastography measurements

06

What researchers measure

Primary outcomes

  1. nerve shear wave velocity

    Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness.

    Time frame: Day0

07

Study locations

1 site
  • Univeristy of Nantes
    Nantes, 44093, France
08

References and documents

Publications

  • Andrade RJ, Nordez A, Magot A, Couloume L, Plancon JP, Quillard JB, Ware RS, Coppieters MW, Pereon Y, Hug F. Ultrasound Shear Wave Velocity of Peripheral Nerves: A Possible Non-Invasive Biomarker for Demyelinating Neuropathies. J Peripher Nerv Syst. 2025 Jun;30(2):e70015. doi: 10.1111/jns.70015. PubMed 40189914 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Apr 2018 to primary completion in Dec 2023, 67 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 5, 2018
First posted
Jan 11, 2018
StartActual
Apr 11, 2018
Primary completionActual
Dec 8, 2023
CompletionActual
Dec 8, 2023
Last update
Sep 14, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03397303
Collaborators
Université de Nantes
Responsible party
Sponsor
First posted
Jan 11, 2018
Start date
Apr 11, 2018
Primary completion
Dec 8, 2023
Completion
Dec 8, 2023
Last update
Sep 14, 2026

Study contacts

Yann Pereon, PU-PH
principal investigator · Nantes University Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.

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