An observational study in Aging, sponsored by University Hospital, Toulouse. Completed at 1 site in France. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-04-29.
Sponsored by University Hospital, Toulouse · Observational
The identification of a high atropine load of treatment received during hospitalization as a predictor of postoperative confusion could have various benefits:
In total, the present study would improve the daily management of hospitalized patients and the practices of clinicians, by offering a decision-making aid.
The recruitment of patients will be ensured from the consultation of anesthesia or the entry into hospitalization by the anesthesia team of the orthopedic surgery department of the Hospital.
Exclusion Criteria:
Data collection of patients admitted to the orthopedic department of the University Hospital of Toulouse for surgical management of a fracture of the upper end of the femur in emergency or for the installation of a hip or knee prosthesis.
Other: Data collection
The collection of data will be done by interrogation of the patient and his family / entourage and rereading of medical records
Association between atropine load of medications on the risk of postoperative confusion
Occurrence of a postoperative confusion syndrome performed by Confusion Assessment Method (CAM) scale once a day. The CAM is a validated scale as a diagnostic scale for confusional syndrome at the patient's bedside with four parts : 1) confusion and fluctuation of symptoms, 2) inattention, 3) disorganization of thought, 4) disorder of consciousness.
Time frame: up to 7 days
Atropinic load of drugs
The DURAN scale is the most recent and most comprehensive atropine load evaluation scale. This scale classifies the evaluated drugs into three categories: no anticholinergic power (atropine weight = 0), low anticholinergic activity (atropine weight = 1), high atropinic power (atropine weight = 3). All drugs received by the patient during 7 days will be classified with the Duran scale.
Time frame: up to 7 days
Duration of hospitalization
Number of days of hospitalization (days) between surgery and discharge. Association between atropinic load of drugs and duration of hospitalization will be evaluated.
Time frame: Up to discharge, an average of ten days
Autonomy
Description of autonomy of the patient at three months of surgery evaluated by the Activity Daily Living scale (ADL). The ADL scale evaluates activities of daily living: washing, dressing, going to the bathroom, ensuring transfers, continence and food. Each item is rated according to a level of dependence: independent (1 point), with assistance (0.5 points), unable to achieve (0 points). A total of 6 points indicates a total autonomy, and 0 a total dependency.
Time frame: Month 3
Cognitive dysfunction
Appearance postoperative cognitive dysfunction by the Mini Mental State (MMS). the total score of MMS wil be collected.
Time frame: baseline
Plan to share: No
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This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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University Hospital, Toulouse