An interventional study of Transcranial Magnetic Stimulation (TMS) and Electrical Muscle Activity (EMG) in Healthy Subject, sponsored by University Hospital, Lille. Terminated at 1 site in France. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-22.
Sponsored by University Hospital, Lille · Not applicable, Interventional, and Basic science
Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.
Exclusion Criteria:
posterior parietal cortex (PPC) transitory inactivation
Device: Transcranial Magnetic Stimulation (TMS) · Device: Electrical Muscle Activity (EMG)
Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.
Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)
Afferent induced facilitation
Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms
Time frame: Baseline
Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI)
Effect of median nerve stimulation on LICI at 100ms interval
Time frame: Baseline
Plan to share: No
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University Hospital, Lille