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CompletedNCT03385694GIROMEETINGUpdated Dec 31, 2018

Long Term Clinical and Functional Outcome in Rotationplasty Patients

An observational study in Disability Physical and Psychological Adaptation, sponsored by Istituto Ortopedico Rizzoli. Completed at 1 site in Italy. Per ClinicalTrials.gov, last updated 2018-12-31.

Sponsored by Istituto Ortopedico Rizzoli · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
30
Sex
All
01

Study summary

Rotationplasty is a very special surgical technique. In its most frequent variant it allows, in the bone sarcomas of the distal femur, to remove all the thigh tissues including the knee joint keeping intact the innervation of the leg and the foot that are transplanted proximally after a 180 ° rotation and joined to the proximal femoral stump.

It is currently the first choice in children under the age of 6 with a bone sarcoma localized to the distal femur but also finds indication in all age groups in cases of extremely voluminous and extended to the entire thigh with the oncological need to remove in block femur, knee and all the muscular involved. The objective of the study is to obtain information about the clinical and functional status of the limb operated in long-term surviving patients. In particular in this study the problem of the possible degenerative pathology of the hip on the operated side will be addressed. Moreover the psychic and psychological well-being of this population with particular reference to gender and motherhood will be tested.

Read the detailed description

30 long term survivors of rotationplasty patients at the IOR will be welcomed by the research team. They will be introduced to the aims of the research and the methodology and timing of the assessment.

The two-day agenda will be communicated to perform in a coordinated manner so that each patient performs all the exams:

  • X ray pelvis
  • Physiatric, orthopedic and prosthetic examination
  • Proprioceptive test with Delos system
  • Psychological questionnaires
02

Conditions studied

  • Disability Physical
  • Psychological Adaptation
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Long survivor patient operated on knee rotationplasty for bone tumors

Inclusion criteria

  • Rotationplasty patients operated at IOR

Exclusion criteria

Exclusion Criteria:

  • Disagreement of patient to participate to the study (or of part of it)
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
30 participants (actual)
Patient registry
No

Groups and cohorts

  • Assessment

    All the patients operated on Van Nes Rotationplasty for bone tumors at IOR and long term surviving

    Diagnostic Test: Assessment

Interventions

  • Diagnostic testAssessment

    Pelvic coronal X-ray, proprioceptive test with Delos system, questionnaires administration, orthopaedic, physiatric and prosthetic assessment

05

What researchers measure

Primary outcomes

  1. Hip X ray assessment

    Pelvic frontal X-ray

    Time frame: 4.12.2017 - 3.12.2018

Secondary outcomes

  1. Physiatric Assessment

    Muscular strenght (MMT)

    Time frame: 4.12.2017 - 3.12.2018

  2. Orthopaedic assessment

    Joints ROM (degrees)

    Time frame: 4.12.2017 - 3.12.2018

  3. Prostheses Assessment

    Leg lenght difference (cm)

    Time frame: 4.12.2017 - 3.12.2018

  4. Symptoms

    Symptom Checklist-90

    Time frame: 4.12.2017 - 3.12.2018

  5. Well being

    Psychological Well-being Scales The Italian validated version, Review of Psychiatry, 2003, 38, 3, pp.117-130) will be used. The reduced version from the 18-item test (3 items for each of the 6 dimensions of psychological well-being) will be used. Each item is assigned a score variable from 1 (= it is not my case / I do not agree) to 6 (= it is just so / perfectly agree). Some items are expressed in negative form and therefore in scoring the score assigned by the subject must be reversed. Adding the scores of the triplets you get a score for each of the 6 dimensions / subscales: autonomy, environmental control, positive relationships with others, self-acceptance, purpose in life and personal growth. Instead, the sum of the value of all 18 items gives an overall value of psychological well-being. At higher scores there is a higher level of well-being (both general and specific for each of the 6 measured dimensions).

    Time frame: 4.12.2017 - 3.12.2018

  6. Psychological status

    Rosenberg Self-Esteem Scale The version translated and validated in Italian by Professor Miretta Prezza of the University of Florence (Bulletin of Applied Psychology, 1997, 223, 35-44) will be used. It measures the attitude towards oneself through 10 items, to which the subject must respond by assigning a score from 1 (strongly disagree) to 4 (strongly agree) The scores of the negative items are reversed. The total score, obtained by adding the scores of the individual items, at higher values corresponds to an attitude more positive towards oneself.

    Time frame: 4.12.2017 - 3.12.2018

  7. Body Image

    Amputees Body Image Scale by James W. Breakey published in the Journal of Prosthetics and Orthotics (Volume 9, Number 2 / Spring 1997). It has never been translated and validated in Italian, it has been translated and adapted (to amputation + gyroplasty) for this study. It evaluates the disturbance in the perception of the body image on a frequency scale (from ever to ever) to 5 points ((1 = never; 5 = always) .It consists of 20 items (3 of which are expressed in 'positive' and therefore to be counted by inverting the score.) The scale gives an overall value (obtained by adding the score of all the items), which goes from 20 to 100: at higher scores there is a greater problematic in the perception of one's body image.

    Time frame: 4.12.2017 - 3.12.2018

  8. Balance assessment

    Delos proprioceptive system

    Time frame: 4.12.2017 - 3.12.2018

06

Study locations

1 site
  • Istituto Ortopedico Rizzoli
    Bologna, 40136, Italy
07

References and documents

Publications

  • Benedetti MG, Okita Y, Recubini E, Mariani E, Leardini A, Manfrini M. How Much Clinical and Functional Impairment do Children Treated With Knee Rotationplasty Experience in Adulthood? Clin Orthop Relat Res. 2016 Apr;474(4):995-1004. doi: 10.1007/s11999-016-4691-9. Epub 2016 Jan 11. Erratum In: Clin Orthop Relat Res. 2016 Apr;474(4):1078-9. doi: 10.1007/s11999-016-4724-4. PubMed 26754115 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03385694
Lead sponsor
Istituto Ortopedico Rizzoli
Responsible party
Mariagrazia Benedetti (MD Director Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli) — Principal investigator
First posted
Dec 28, 2017
Start date
Nov 23, 2017
Primary completion
Feb 19, 2018
Completion
Dec 3, 2018
Last update
Dec 31, 2018

Study contacts

Maria Grazia Benedetti
principal investigator · Istituto Ortopedico Rizzoli

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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