An interventional study of Strawberry juice with Inulin and Strawberry Juice in Healthy, sponsored by University of Glasgow. Completed at 1 site in United Kingdom. Open to participants aged 20 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-07-12.
Sponsored by University of Glasgow · Not applicable, Interventional, and Basic science
This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. We hypothesize that combination of dietary polyphenolics and non-digestible carbohydrates (NDC) will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomised order: Strawberry juice (a high polyphenol food), Inulin (NDC) or Mixture of strawberry juice and inulin.
Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols. The colonic microbiota are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as dietary fibre to short chain fatty acids. It is likely that there are key interactions in the colonic bacteria metabolism of fibre and phenolics. We hypothesize that combination of polyphenolics and non-digestible carbohydrates (NDC) will increase the urinary output of bioactive phenolic acids.
This study will enable a better understanding of how to deliver combinations of ingredients and nutrients to achieve maximum nutritional value and health benefits.
Self-reported healthy adults
Exclusion Criteria:
Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.
One dose of 300 g of strawberry with 10 g of inulin will be given to subjects in the form of juice
Dietary Supplement: Strawberry juice with Inulin
One dose of 300 g of strawberry juice will be given to subjects in the form of juice
Dietary Supplement: Strawberry Juice
One dose of 10 g of inulin will be given to subjects in the form of a drink
Dietary Supplement: Inulin
Mixture of polyphenols and non digestible carbohydrates
Source of Polyphenols
Source of non digestible carbohydrate
Phenolic acids bioavailability
Urine excretion of phenolic acids
Time frame: 0-24 hrs
Urolithin bioavailability
Urine excretion of urolithins
Time frame: 0-24 hrs
Glycaemic and appetite hormones measurements by ELISA
Plasma glucose, insulin and appetite hormone levels
Time frame: 0-8 hrs
Mouth to caecum transit time
Breath hydrogen level measurements by Hydrogen monitor
Time frame: 0-8 hrs
Gastric emptying time
Plasma paracetamol levels by acetaminophen assay kits
Time frame: 0-6 hrs
This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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University of Glasgow