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WithdrawnNCT03372070Updated Oct 2, 2019

Continuous Negative External Pressure for the Treatment of Primary Snoring

An interventional study of cNEP in Snoring, sponsored by Sommetrics, Inc.. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2019-10-02.

Sponsored by Sommetrics, Inc. · Not applicable, Interventional, and Treatment

Why this study was withdrawn
Administrative reasons
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Not applicable
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The aim of this pilot study is to gain information on the ability of a continuous negative external pressure collar to safely reduce snoring in primary snorers, and if so to determine whether the reduction in snoring has benefits for both the snorer and the bed partner. This clinical trial will involve both the snorer and his or her bed partner, both of whom must qualify and provide informed consent for participation.

02

Conditions studied

  • Snoring

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Keywords

  • primary snoring
  • bed partner
  • home sleep testing
03

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Key Snorer Inclusion Criteria:

  • BMI \<35
  • if a previously done polysomnogram (PSG) is available, AHI\<5
  • snoring identified by a previous PSG and/or by the bed partner

Key bed partner Inclusion criteria

  • must have regularly slept with the snorer over the previous month and must plan to sleep with the snorer for the duration of the trial
  • considers that the snorer's snoring is a problem
  • must discontinue use of any snore-masking equipment or ear plug for at least two weeks prior to the initial visit to the study site and agree to refrain from their use for the duration of the trial

Key snorer exclusion criteria:

  • sleep disturbance other than snoring
  • snoring due primarily to abnormality of the nasopharynx
  • use of snoring treatment during the month prior to the initial visit
  • neck anatomic or skin abnormalities
  • serious medical condition
  • excessive drug or alcohol intake

Key bed partner exclusion criteria:

-known sleep disorder

04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    cNEP

    silicone collar applied to anterior neck

    Device: cNEP

Interventions

  • DevicecNEP

    soft silicon collar applied to anterior neck with negative pressure

    Also known as: continuous negative external pressure

05

What researchers measure

Primary outcomes

  1. change in snoring duration

    duration of snoring as a percent of total sleep time compared to baseline

    Time frame: two weeks after initiation of treatment

Secondary outcomes

  1. change in apnea-hypopnea index (AHI)

    mean AHI compared to baseline

    Time frame: two weeks after initiation of treatment

  2. change in snoring intensity

    mean dBC compared to baseline

    Time frame: two weeks after initiation of treatment

  3. Treatment-emergent adverse events

    tabulation of all adverse events during the clinical trial

    Time frame: two weeks

  4. change in Epworth Sleepiness Scale (ESS)

    mean ESS compared to baseline (total range 0-24; lower score means less sleepy)

    Time frame: two weeks after initiation of treatment

  5. Short Form Survey 36 (SF-36)

    mean SF-36 compared to baseline

    Time frame: one week time frame, administered two weeks after initiation of treatment

  6. Clinical Global Impression (CGI) Scale: Snorer's sleep

    CGI "usual sleep score" vs baseline (score range "very much better to very much worse"

    Time frame: previous week, assessed one and two weeks after initiation of treatment

  7. Clinical Global Impression (CGI) Scale: Bed partner's complaints about snoring

    CGI "bed partner complaints about your snoring" scale vs baseline (score range "complained very much less, to "complained very much more"

    Time frame: previous week, assessed one and two weeks after initiation of treatment

  8. Clinical Global Impression (CGI) Scale: Acceptability of cNEP

    CGI "bed partner complaints about your snoring" scale vs baseline (score range "complained very much less, to "complained very much more"

    Time frame: "overall experience to date", assessed one and two weeks after initiation of treatment

  9. Clinical Global Impression (CGI) Scale: Bed partner's impression of snorer's sleep

    CGI scale comparing snorer's sleep to baseline (score range "very much better to very much worse"

    Time frame: previous week, assessed one and two weeks after initiation of treatment

  10. Clinical Global Impression (CGI) Scales: bed partner's sleep

    CGI scale comparing bed partner's sleep to baseline (score range "very much better to very much worse"

    Time frame: previous week, assessed one and two weeks after initiation of treatment

  11. Clinical Global Impression (CGI) Scale: Bed partner's overall relationship with snorer

    CGI scale comparing bed partner's overall relationship wtih snorer to baseline (score range "very much better to very much worse"

    Time frame: previous week, assessed one and two weeks after initiation of treatment

06

Study locations

1 site
  • Cleveland Clinic
    Cleveland, Ohio 44195, United States
07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03372070
Lead sponsor
Sommetrics, Inc.
Responsible party
Sponsor
First posted
Dec 13, 2017
Start date
Jan 2021 (estimated)
Primary completion
Jan 2022 (estimated)
Completion
Jan 2023 (estimated)
Last update
Oct 2, 2019

Study contacts

Reena Mehra, MD
principal investigator · Cleveland Clinic Lerner College of Medicine

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.

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