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TerminatedNCT02767843Updated May 7, 2024Results posted

Pilot Study of cNEP for the Treatment of Snoring

An interventional study of continuous negative external pressure (cNEP) in Snoring, sponsored by Sommetrics, Inc.. Terminated at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2024-05-07.

Sponsored by Sommetrics, Inc. · Not applicable, Interventional, and Treatment

Why this study was terminated
Recruiting sufficient number of qualified subjects proved impossible.
Phase
Not applicable
Study type
Interventional
Enrollment
4
Allocation
Not applicable
Ages
18 Years to 70 Years
Sex
All
01

Study summary

This pilot study will examine the efficacy and safety of continuous negative external pressure ("cNEP") for the treatment of chronic snoring in people without obstructive sleep apnea.

02

Conditions studied

  • Snoring

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03

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • sleep test within the previous six months that shows snoring of at least 30 dB for at least 30% of total sleep time
  • AHI \< 10/hr

Exclusion criteria

Exclusion Criteria:

  • previous neck surgery or radiation
  • carotid artery disease
  • serious medical or psychiatric illness
  • pregnancy
  • silicone allergy
  • excessive use of alcohol or sedating drugs
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
4 participants (actual)

Study arms

  • Experimental
    treatment

    continuous negative external pressure (cNEP) at various negative pressures

    Device: continuous negative external pressure (cNEP)

Interventions

  • Devicecontinuous negative external pressure (cNEP)

    soft silicone collar placed on the anterior neck, to which a negative pressure is introduced

05

What researchers measure

Primary outcomes

  1. Response

    snoring decreased by \<50% from baseline

    Time frame: one night

  2. Adverse Events

    all adverse events

    Time frame: one night

Secondary outcomes

  1. Complete Response

    snoring for \< 5% of total sleep tim

    Time frame: one night

06

Results

Posted Mar 24, 2017
Limitations and caveats
Early termination due to difficulty of recruitment. Technical problems with measurements, so data were uninterpretable.

Participant flow

Participant flow — Overall Study
MilestoneSubjects
Started4
Completed4
Not completed0

Outcome measures

PrimaryResponse

snoring decreased by \<50% from baseline

Time frame:
one night

No measurements were reported for this outcome.

PrimaryAdverse Events

all adverse events

Time frame:
one night
Reported as:
Count of participants · Participants
Adverse Events
ParticipantsSubjects
Adverse Events1
SecondaryComplete Response

snoring for \< 5% of total sleep tim

Time frame:
one night

No measurements were reported for this outcome.

Adverse events

Collected over entire study duration. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
All Subjects—0/4 (0%)1/4 (25%)
Most frequent other events
Most frequent other events
EventAll Subjects
minor erythemaSkin and subcutaneous tissue disorders1/4

Baseline characteristics

all subjects who underwent cNEP usage

Age, Categorical
Age, Categorical(Participants)Treatment
<=18 years0
Between 18 and 65 years4
>=65 years0
Age, Continuous
Age, Continuous(years)Treatment
Mean42 (33 to 57)
Sex: Female, Male
Sex: Female, Male(Participants)Treatment
Female3
Male1
Region of Enrollment
Region of Enrollment(participants)Treatment
United States4
07

Study locations

1 site
  • California Center for Sleep Disorders
    Alameda, California 94501, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Registry details

Key details

Study ID
NCT02767843
Lead sponsor
Sommetrics, Inc.
Responsible party
Sponsor
First posted
May 10, 2016
Start date
May 2016
Primary completion
Nov 2016
Completion
Dec 2016
Results posted
Mar 24, 2017
Last update
May 7, 2024

Study contacts

Jerrold Kram, MD
principal investigator · California Center for Sleep Disorders, Alameda, CA

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is terminated, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.

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