An interventional study of Mental fatigue and Control in Mental Fatigue and Healthy, sponsored by Vrije Universiteit Brussel. Completed at 1 site in Belgium. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-10-08.
Sponsored by Vrije Universiteit Brussel · Not applicable, Interventional, and Basic science
To assess the changes in brain activation and cerebral blood flow due to mental fatigue in a placebo-controlled study. More specifically we want to assess whether brain activation [measured with Blood Oxygen Level Dependent (BOLD) functional resonance imaging (fMRI)] is decreased during a Flanker task in a mentally fatigued state and whether this coincides with a decline in cognitive performance. In addition we also want to evaluate whether cerebral blood flow [measured with arterial spin labeled (ASL) fMRI] in a resting state is reduced when mentally fatigued.
159 studies on the registry are indexed under Mental Fatigue; 55 are open to participants now.
This study's enrollment of 20 is below the median of 45 across 129 interventional studies indexed under Mental Fatigue.
Browse Mental Fatigue studies →Vrije Universiteit Brussel is the lead sponsor of 157 studies on the registry; 44 are open to participants now.
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Exclusion Criteria:
A modified Stroop task of 90 min, partitioned in 8 blocks of 252 stimuli, will be used as mentally fatiguing task.
Other: Mental fatigue
In the control task subjects will have to watch a documentary on the same computer screen as that used for the experimental trial for 90 min.
Other: Control
A modified Stroop task of 90 min, partitioned in 8 blocks of 252 stimuli, will be used as mentally fatiguing task. The Stroop task requires inhibition and sustained attention on controlled processes.
In the control task subjects will have to watch a documentary on the same computer screen as that used for the experimental trial. These documentaries are chosen based on their emotionally neutral, yet engaging content.
Blood Oxygen Level Dependent - Signal during a 10-min cognitive task (i.e. Flanker task)
Blood Oxygen Level Dependent - Signal will be measured during a 10-min Flanker task that will be completed immediately before and after the 90-min task (i.e. documentary in control trial; stroop task in intervention trial)
Time frame: Blood Oxygen Level Dependent - Signal will be measured during a 10-min Flanker task that will be completed immediately prior and after the 90-min task that is completed in both trials.
Plan to share: No
Ran from Feb 2018 to primary completion in Nov 2018, 9 months.
Of 74 non-industry interventional studies with no phase under Mental Fatigue, half reached primary completion within 9 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 23. This study's 9 months is close to that.
Counting every sponsor, half of 87 studies reached it within 7 months; a quarter within 3 and three quarters within 22.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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