ClinicalTrials.gg
CompletedNCT03358758Updated Dec 2, 2017

Retrospective Morbidity and Mortality Study of Conflict-Related Injuries: Erbil, Iraq

An observational study in Wounds and Injuries, War-Related Injuries and Gunshot Wound, sponsored by Karolinska Institutet. Completed at 1 site in Sweden. Open to participants aged Up to 99 Years. Per ClinicalTrials.gov, last updated 2017-12-02.

Primary conditionBlast InjuriesRegistry: Wounds and InjuriesReclassifiedWhy we changed it
Registry
Wounds and Injuries — the first condition term the registry derived for this study.
ClinicalTrials.gg
Blast Injuries
Why
  1. The study's listed conditions name Blast Injuries, a narrower term within Wounds and Injuries.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Karolinska Institutet · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,832
Ages
Up to 99 Years
Sex
All
01

Study summary

A retrospective morbidity and mortality study, using routinely collected data, investigating the epidemiology of patients with conflict-related injuries presenting to a dedicated trauma hospital in Erbil, Iraq, during the campaign to liberate Mosul from ISIS.

Read the detailed description

Trauma is a major cause of morbidity and mortality worldwide. An analysis of the Global Burden of Disease study indicated that in 2013, globally 973 million traumatic injuries warranted medical intervention, while 4.8 million injuries were fatal. The Small Arms Survey - Global Burden of Armed Violence report compiles worldwide conflict-related data and indicates that between 2007-2012, there were a total of 508,000 fatalities attributable to interpersonal violence worldwide, of which 70,000 were conflict-related. Since the U.S. invasion of Iraq in 2003, the country has perpetually constituted a scene of conflict. Hagopian et al reports that in the period 2003-2011, there were between 48,000 and 751,000 excess deaths attributable to the conflict.

In 2014, a new group, Islamic State of Iraq and Syria (ISIS), made significant territorial gains in several governorates in Iraq and captured key cities, including Fallujah and Mosul. ISIS is unique among terrorist groups in that it employs a combination of conventional maneuver warfare tactics with terrorist tactics such as Improvised Explosive Devices (IEDs) and Vehicle-Born Improvised Explosive Devices (VBIEDs) in order to capture and hold territory. These indiscriminate tactics lead to excessive civilian casualties.

In mid-October 2016 the offensive to liberate Mosul started. Emergency Hospital (EH) is one hospital assigned by the Kurdistan Ministry of Health to receive trauma patients from the conflict, and is located in Erbil, around 94 Km east of Mosul. EH is a dedicated trauma hospital that was set up in 1997. Since mid-October 2016 EH is exclusively providing care to injured from the armed conflict. Initially EH and WEH were the only hospitals providing surgical trauma care to patients from Mosul but since late December 2016 secondary facilities have opened closer to Mosul. The two hospitals are since then mainly referral hospitals.

Previous research on trauma from conflict zones generally focus solely on military combatants. Due to the use of ballistic protection and forward surgical teams these results may not be applicable to a civilian setting. A few organizations, such as the Médecins Sans Frontières (MSF), have reported on civilian casualties in conflict zones; however, these have been reports from single centers and articles are sometimes published several years after the trauma occurred. More timely information is needed on the type and pattern of injury for both combatants and civilians. ISIS tactics are likely to have a significant impact on the type of injuries seen at EH. An increased understanding of this impact is essential for addressing emerging resource requirements. The investigators anticipate a high incidence of blast- and firearm-related injuries in both civilians and combatants. This study utilizes existing data from the hospital to gain knowledge of the characteristics of conflict-related injuries, as well as the demographic profile of the patients. Furthermore, the data will be used to investigate how morbidity and mortality varies depending on injury type.

Specific aims:

  1. Describe the demographics of patients with conflict-related injuries presenting to the EMC during the Mosul campaign.
  2. Describe the morbidity profile of the study population, specifically:

    1. Determine how markers for injury severity vary with injury mechanism and patient status as combatant or non-combatant.
    2. Compare how injury mechanism varies with patient identity as non-combatant, ISF or Peshmerga.
  3. Determine the in-hospital mortality rate.

This is essential both for generating actionable results necessary to direct operational priorities, and gaining an understanding of the wider public health impact of the ongoing conflict. The evidence generated by this study will facilitate effective programmatic monitoring and help optimize resource allocation to meet the rapidly changing health needs in the area.

02

Conditions studied

  • Wounds and Injuries
  • War-Related Injuries
  • Gunshot Wound
  • Blast Injuries

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Keywords

  • Trauma
  • War-Related Injuries
  • Firearm
  • Explosion
  • Bomb
  • Ordnance
  • IED
  • Epidemiology
  • Public Health
03

In context

Blast Injuries Reclassified

24 studies on the registry are indexed under Blast Injuries; 7 are open to participants now.

This study's enrollment of 1,832 is above the median of 100 across 13 observational studies indexed under Blast Injuries.

Browse Blast Injuries studies →

Lead sponsor

Karolinska Institutet is the lead sponsor of 1,148 studies on the registry; 276 are open to participants now.

Compared within Blast Injuries, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Wounds and Injuries. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
Up to 99 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Civilians and combatants injured in Mosul

Eligibility criteria

Inclusion criteria: All patients from Mosul presenting with conflict-related injuries to Emergency Hospital between October 16, 2016 to July 10, 2017.

-

Exclusion Criteria:

  • Non-conflict related injures, Patients not categorised as either civilian or combatant
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,832 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Morbidity

    Site of injury, mechanism of injury, patient status as combatant or non-combatant

    Time frame: October 16, 2016 to July 10, 2017

  2. Mortality

    In-hospital mortality

    Time frame: October 16, 2016 to July 10, 2017

07

Study locations

1 site
  • Karolinska Institute
    Stockholm, Sweden
08

References and documents

Publications

  • Nerlander MP, Haweizy RM, Wahab MA, Alga A, von Schreeb J. Epidemiology of Trauma Patients from the Mosul Offensive, 2016-2017: Results from a Dedicated Trauma Center in Erbil, Iraqi Kurdistan. World J Surg. 2019 Feb;43(2):368-373. doi: 10.1007/s00268-018-4817-1. PubMed 30357467 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 2, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03358758
Responsible party
Maximilian Nerlander (Dr, Karolinska Institutet) — Principal investigator
First posted
Dec 2, 2017
Start date
Oct 16, 2016
Primary completion
Jul 10, 2017
Completion
Jul 10, 2017
Last update
Dec 2, 2017

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Nov 2017. You cannot join it, but the record below documents what was studied.

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