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Status unknownNCT03358641Updated Nov 30, 2017

The Relationship Between Physical Activity and Radiographic Osteoarthritis Worsening

An observational study in Osteoarthritis, Knee, sponsored by Peking University People's Hospital. Status unknown. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2017-11-30.

Sponsored by Peking University People's Hospital · Observational

The sponsor has not verified this record recently (last verified Nov 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,200
Ages
50 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 10 studies in Osteoarthritis, Knee by Peking University People's Hospital — none open to participants now, none under way, none of them phase 3. Osteoarthritis, Knee · Peking University People's Hospital.

Started
2018
with 8 others
Observational
Only one
of the 10
Registered
1st of 10
by date

Among the 10 studies in Osteoarthritis, Knee by Peking University People's Hospital, this one is one of 9 that started in 2018, is the only observational one, and was the 1st registered.

Osteoarthritis, Knee

3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.

Browse Osteoarthritis, Knee studies →

Open to participants now

None of the 10 studies in Osteoarthritis, Knee by Peking University People's Hospital is open now.

Where they have run

Who these studies take

Of the 382 Osteoarthritis, Knee studies recruiting now, 176 (46%) set no upper age limit and 113 (30%) stop at 75 or younger; 19 take children under 18; 39 take healthy volunteers.

This study: 50 Years and older · all sexes.

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Download CSVNarrow it in search →With an account: the 10 studies in Osteoarthritis, Knee by Peking University People's Hospital as a file.
02

Study summary

Wuchuan Osteoarthritis Study is a population-based longitudinal study of natural history of knee osteoarthritis and its risk factors. At baseline and follow-up visits, IPA-Q questionnaire and a radiographs at tibiofemoral (TF) joints will be taken in order to assess the relationship between physical activity and radiographic osteoarthritis worsening.

Read the detailed description

1025 residents aged ≥ 50 years will be recruited using door-to-door enumeration in randomly selected rural communities in Wuchuan, China, and will be followed in 3 years. At baseline and follow-up visits, subjects will complete a home interview (including, but not limited to, socio-demographic factors, physical activity level using IPA-Q questionnaire,WOMAC questionnaire) and have a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints. Radiographic osteoarthritis (ROA) worsening for a knee is defined if its Kellgren and Lawrence (K/L) grade increases by at least 1 grade except for the change from 0 to 1 during follow-up. The relationship between level of physical activity and ROA worsening will be assessed.

03

Conditions studied

  • Osteoarthritis, Knee

Keywords

  • exercise
  • physical activity
  • radiographic osteoarthritis
04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Sampling method
Probability sample

Study population

People, over 50 years old, in a rural area in Northern China (Wuchuan, Inner Mongolia)

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. people aged 50 or over
  2. Wuchuan permanent resident population

Exclusion criteria

Exclusion Criteria:

  1. patients with rheumatoid arthritis
  2. the disabled
  3. patients with mental disorders
  4. laid up for malignant tumor
  5. people who live or work outside for more than half a year
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Wuchuan residents

    All residents that meet the criteria can be enrolled in this group, receiving a home interview (including IPA-Q to assess the level of physical activity) and a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints at baseline and 3 years later.

    Other: level of physical activity

Interventions

  • Otherlevel of physical activity

    According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.

06

What researchers measure

Primary outcomes

  1. worsening of radiographic osteoarthritis

    The tibiofemoral radiograph of both knee joint will be taken at baseline and in 3 years. Knee radiographs will be read by one investigator according to Kellgren and Lawrence (K/L) criteria. A knee will be defined as ROA worsening if its K/L grade increased by at least 1 grade except for the change from 0 to 1 during follow-up.

    Time frame: 3 years after enrollment

Secondary outcomes

  1. The Western Ontario and McMaster Universities Osteoarthritis Index

    The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) will be assessed at baseline and in 3 years, from which symptoms of patients can be estimated.

    Time frame: 3 years after enrollment

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Jan 2018; primary completion for Dec 2020, 35 months later.

Of 179 non-industry observational studies under Osteoarthritis, Knee, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 48. This study's planned 35 months is above that.

Counting every sponsor, half of 220 studies reached it within 24 months; a quarter within 14 and three quarters within 61.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 25, 2017
First posted
Nov 30, 2017
StartEst.
Jan 1, 2018
Primary completionEst.
Dec 31, 2020
CompletionEst.
Dec 31, 2020
Last update
Nov 30, 2017
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 30, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03358641
Responsible party
Lin Chutong (arthritis clinic and research center, Peking University People's Hospital) — Principal investigator
First posted
Nov 30, 2017
Start date
Jan 1, 2018 (estimated)
Primary completion
Dec 31, 2020 (estimated)
Completion
Dec 31, 2020 (estimated)
Last update
Nov 30, 2017

Study contacts

Chutong Lin
Contact
chutonglin@126.com
+86 15652930253
Jianhao Lin, MD
principal investigator · arthritis clinic and research center

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2017. You cannot join it, but the record below documents what was studied.

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