An observational study in Schizophrenia, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Completed at 1 site in France. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-17.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Observational
Childhood trauma is known as a vulnerability factor in schizophrenia. In healthy volunteers, these adversities are linked to a decrease of grey matter of the brain, similar to those observed in schizophrenia.
In a previous study based on Voxel-Based Morphometry (VBM), including 21 schizophrenic patients and 30 healthy volunteers, the investigators shown a negative correlation between emotional neglect (important dimension in childhood trauma) and grey matter decrease. This strong correlation was significantly higher in schizophrenic patients than in healthy volunteers, suggesting a higher genetic predisposition to environmental factors in schizophrenic people.
Currently, interaction between genetic predisposition and environmental stress factors is the major model for understanding in schizophrenia. In order to analyze both effects on human body, particularly on brain, several studies currently focus on the product of genetic expression, the ribonucleic acid (ARN).
The purpose of this study is to provide an explanatory model of links between childhood trauma, candidate gene for schizophrenia expression, cerebral morphology and schizophrenic symptomatology. Using conceptual framework of stress vulnerability, structural equation modeling (SEM) will allow testing causal link between these different variables.
Schizophrenic patients, related volunteers (first degree relative of patient) and healthy volunteers
Inclusion Criteria of patients :
Exclusion Criteria of patients :
Inclusion Criteria of Related volunteers :
Exclusion Criteria of Related volunteers :
Inclusion Criteria of Healthy volunteers :
Exclusion Criteria of Healthy volunteers :
Beside the absence of schizophrenia diagnosis, healthy volunteers should meet the same exclusion criteria as patients
Patients will have clinical psychiatric evaluation, brain imaging and blood sample
Device: magnetic resonance imaging (MRI) · Procedure: Blood sample · Other: Clinical psychiatric evaluation
Related volunteers will have clinical psychiatric evaluation, brain imaging and blood sample
Device: magnetic resonance imaging (MRI) · Procedure: Blood sample · Other: Clinical psychiatric evaluation
Healthy volunteers will have clinical psychiatric evaluation, brain imaging and blood sample
Device: magnetic resonance imaging (MRI) · Procedure: Blood sample · Other: Clinical psychiatric evaluation
brain imaging : structural anatomy, emotional congruence, anatomic connectivity, functional connectivity
27,5 ml of blood sample : genetic analysis and biobank
Global Assessment Scale(GAS),Mini International Neuropsychiatric Interview(MINI),Positive and Negative Symptoms Scale(PANSS),Family Interview for Genetic Studies(FIGS),Calgary Depression Scale for Schizophrenia(CDSS),extrapyramidal side effects evaluation or Simpson-Angus scale evaluation(ESRS),Apathy Evaluation Scale(AES-C),State-Trait Anxiety Inventory(STAI),Beck Depression Inventory(BDI-13),Eysenck Personality Questionnaire-Revised(EPQ-R),Assessment of Schizotypal Personality(SPQ),Emotion Regulation Questionnaire(ERQ),Emotional Reactivity Scale(ERS),Toronto Alexithymia Scale(TAS-20),social anhedonia scale(SAS),Childhood Trauma Questionnaire(CTQ),Clinical-administered Post Traumatic Stress Disorder Scale(CAPS),Wechsler Adult Intelligence Scale(WAIS-III),Trail Making Test(TMT),Pen and paper visuospatial working memory(DOT-test),impulsivity test(GoStop),Stroop test,National Adult Reading Test(NART),Wechsler Adult Intelligence Scale(WAIS-III),Facial Emotion Recognition task(FER)
Childhood Trauma Questionnaire (CTQ) for childhood trauma.
development of an etiopathogenic model characteristic of schizophrenia Childhood Trauma Questionnaire : to assess five types of childhood trauma : 1. Emotional neglect 2. physical abuse 3. emotional abuse 4. physical neglect 5. sexual abuse Each item being rated in 5 answer choice from 1 to 5 (never, rarely, sometimes, often or very often)
Time frame: 5 days
Quantitative measurement of RNAs
development of an etiopathogenic model characteristic of schizophrenia
Time frame: 5 days
Voxel-based morphometry (VBM) for total gray matter
development of an etiopathogenic model characteristic of schizophrenia
Time frame: 5 days
Voxel-based morphometry (VBM) for regional gray matter density.
development of an etiopathogenic model characteristic of schizophrenia
Time frame: 5 days
Connectivity in the cortico-limbic circuit
Time frame: 5 days
Volumetry of the brain
Time frame: 5 days
Correlation of BOLD activity in the cortico-limbic circuit in patients with patients with symptomatic variables
symptomatic variables : PANSS scale
Time frame: 5 days
Correlation of BOLD activity in the cortico-limbic circuit with emotional variables
emotional variables : ERS scale, ERQ scale, TAS-20 scale, SAS scale, AES-C scale
Time frame: 5 days
Correlation of BOLD activity in the cortico-limbic circuit with personality characteristics
personality characteristics : EPQ-R scale, SPQ scale
Time frame: 5 days
Correlation of BOLD activity in the cortico-limbic circuit with history of trauma in childhood
history of trauma in childhood : CTQ scale
Time frame: 5 days
Plan to share: No
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Centre Hospitalier Universitaire de Saint Etienne