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TerminatedNCT03323255PPCstimUpdated May 15, 2026

rTMS Posterior Parietal Cortex Modulation and Upper Limb Movement After Stroke

An interventional study of repeated transcranial magnetic stimulation continuous theta-burst stimulation and SHAM repeated transcranial magnetic stimulation in Stroke, Hemiparesis and Transcranial Magnetic Stimulation, sponsored by University Hospital, Lille. Terminated at 1 site in France. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-05-15.

Sponsored by University Hospital, Lille · Not applicable, Interventional, and Basic science

Why this study was terminated
COVID
Phase
Not applicable
Study type
Interventional
Enrollment
1
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 15 studies in Stroke by University Hospital, Lille — 4 open to participants now, 4 under way, none of them phase 3. Stroke · University Hospital, Lille.

Started
2020
the only one that year
No phase
7 of 15
2 open now
Registered
8th of 15
by date

Among the 15 studies in Stroke by University Hospital, Lille, this one is the only one that started in 2020, is one of 7 with no phase, and was the 8th registered.

Stroke

8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.

This study's enrollment of 1 is below the median of 49 across 6,024 interventional studies indexed under Stroke.

Browse Stroke studies →

Open to participants now

4 of the 15 studies in Stroke by University Hospital, Lille are open now, in 1 country. Each count lists the studies.

All 4 open studies →

Where they have run

Who these studies take

Of the 1,415 Stroke studies recruiting now, 697 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 196 take healthy volunteers.

This study: 18 Years to 80 Years · all sexes · no healthy volunteers.

The full table on the hub →
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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 15 studies in Stroke by University Hospital, Lille, or all of them as a file.
02

Study summary

This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.

To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.

03

Conditions studied

  • Stroke
  • Hemiparesis
  • Transcranial Magnetic Stimulation
  • Brain Connectivity

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04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age between 18 and 80y
  • Right-handed
  • Right hemispheric stroke confirmed by a 3D imaging technique
  • at the chronic phase (>6months)
  • subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk
  • Social security affiliation

Exclusion criteria

Exclusion Criteria:

  • Severe comprehension troubles (language, cognitive or psychiatric disorders)
  • History of neurological disorders in addition to the stroke
  • Locomotor troubles affecting the paretic arm
  • to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness
  • pregnancy or breastfeeding
  • adult subject to guardianship
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
1 participant (actual)

Study arms

  • Active comparator
    cTBS stimulation

    continuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses)

    Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation

  • Sham comparator
    SHAM stimulation (placebo)

    SHAM stimulation

    Device: SHAM repeated transcranial magnetic stimulation

Interventions

  • Devicerepeated transcranial magnetic stimulation continuous theta-burst stimulation

    cTBS

  • DeviceSHAM repeated transcranial magnetic stimulation

    SHAM stimulation

06

What researchers measure

Primary outcomes

  1. Time of movement during the pointing movement

    Time between the initiation of the movement and the reaching of the target

    Time frame: 30 minutes

Secondary outcomes

  1. Reaction time (time between the go signal and th onset of the movement)

    temporal parameters of pointing movements

    Time frame: 30 minutes

  2. Response time (time between the go signal and the reaching of the target)

    temporal parameters of pointing movements

    Time frame: 30 minutes

  3. Peak velocity of the hand during the pointing movement

    pak velocity in m/s

    Time frame: 30 minutes

  4. smoothness (number of units of movement during the pointing movement),

    Spatial parameters of pointing movements

    Time frame: 30 minutes

  5. Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target)

    Spatial parameters of pointing movements

    Time frame: 30 minutes

  6. Detection of mirror movements with the healthy upper limb

    EMG detection

    Time frame: 30 minutes

  7. Primary motor cortex excitability of both motor cortices

    Resting motor threshold of lesioned and non-lesioned hemispheres

    Time frame: 30 minutes

  8. Parietomotor connectivity in the contralesional hemisphere

    Assessed by a paired-pulse TMS protocol (see Allart et al. 2017 for more details)

    Time frame: 30 minutes

  9. Spatial bias

    Line bisection test

    Time frame: 30 minutes

07

Study locations

1 site
  • Hôpital Swynghedauw, CHU lille
    Lille, 59037, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Mar 2020 to primary completion in Aug 2021, 16 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 16, 2017
First posted
Oct 26, 2017
StartActual
Mar 10, 2020
Primary completionActual
Aug 1, 2021
CompletionActual
Aug 1, 2021
Last update
May 15, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03323255
Responsible party
Sponsor
First posted
Oct 26, 2017
Start date
Mar 10, 2020
Primary completion
Aug 1, 2021
Completion
Aug 1, 2021
Last update
May 15, 2026

Study contacts

Etienne Allart, MD
principal investigator · University Hospital, Lille

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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