MacTel Laser Study

1. Signed and dated written informed consent obtained from the participant in accordance with the local regulations;
2. Males/females 21 years of age and older but less than 80 years of age;
3. Participant must have a positive diagnosis of MacTel Type 2 in at least one eye with evidence of fluorescein leakage typical of MacTel or at least one of the other features including loss of retinal transparency/hyper-reflectivity to blue light, crystalline deposits, right angle vessels, inner/outer retinal low-reflective spaces, or hyperpigmentation not involving the center of the fovea, but no evidence of intraretinal/subretinal vascular proliferation;
4. Participant must have an Ellipsoid Zone (EZ, aka IS/OS) break in the study eye between 0.16 - 4.0 mm2 as measured on SD-OCT;
5. Participant's best-corrected visual acuity at least 55 letters (20/80) in the study eye;
6. Participant must have steady fixation in the foveal or parafoveal area of each eye, adequate pupil dilation and sufficiently clear media to perform multi-modal retinal imaging and treatment;

7. Participant must be able and willing to attend all scheduled visits.

   For Participants undergoing optional AOSLO imaging:

8. Participant should have reproducible baseline AOSLO image montages at 2 baseline imaging sessions with quality suitable to identify a minimum of 7 regions of interest (ROIs) at which reliable cone spacing measures can be made in each eye.

Exclusion Criteria:

1. Participant is unable to provide informed consent;
2. Participant is less than 21 years of age or greater than 80 years of age; (but less than 80);
3. Participant is medically unable to comply with study procedures or follow-up visits;
4. Participant received intravitreal therapy for non-neovascular MacTel in the study eye and in the fellow eye, injections no sooner than 3 months prior to study treatment;
5. Participant has nystagmus in either eye;
6. Participant has greater than 7 diopters myopia in either eye;
7. Participant has been diagnosed and treated for amblyopia in the study eye;
8. Participant has significant ocular abnormalities in either eye that prevent retinal assessment, including media opacities or cataract (up to Nuclear Sclerosis +1 is allowable);
9. Participant was a study participant in any other clinical trial of an intervention (drug or device) within the last 6 months;
10. Participant has a history of malignancy that would compromise the 12 month study survival; or
11. Participant has, in the opinion of the Investigator, any physical or mental condition that would increase the patient's risk of participation in the study or may interfere with the study procedures, evaluations and outcome assessments;
12. Presence of signs of advanced retinal/vascular disease in the study eye, such as CNV, haemorrhages or macular atrophy based on OCT or FAF;
13. Previous macular laser treatment in either eye;
14. Any previous ocular condition that may be associated with a risk of developing macular oedema;
15. Vitreomacular traction determined clinically and/or by OCT, which in the opinion of the investigator contributes to the macular oedema (associated or causing a detachment of the fovea) in the study eye;
16. Presence of other macular disease such as epiretinal membrane in the study eye;
17. Ocular or periocular infections;
18. Planned intra-ocular surgery in the study eye within one year; and
19. Patient is unavailable for follow-up visits.