ClinicalTrials.gg
CompletedNCT03319147Updated Apr 20, 2021

Effect of Amino Acid on Muscle Damage

An interventional study of Active and Placebo in Healthy, sponsored by University of Toronto. Completed at 1 site in Canada. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-04-20.

Sponsored by University of Toronto · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Male
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 31 studies in Motor Activity by University of Toronto — 12 open to participants now, 14 under way, none of them phase 3. Motor Activity · University of Toronto.

Enrollment
21st of 28
20 · median 31
Started
2017
with 1 other
No phase
28 of 31
10 open now
Registered
7th of 31
by date

Among the 31 studies in Motor Activity by University of Toronto, this one is the 21st largest by enrollment of the 28 interventional ones that give a count, is one of 2 that started in 2017, is one of 28 with no phase, and was the 7th registered.

Motor Activity

9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.

Browse Motor Activity studies →

Open to participants now

12 of the 31 studies in Motor Activity by University of Toronto are open now, in 1 country. Recruiting first, the newest first:

7 more — sign in →

By country, each count listing its studies:

All 12 open studies →

Where they have run

Who these studies take

Of the 1,201 Motor Activity studies recruiting now, 517 (43%) set no upper age limit and 535 (45%) stop at 75 or younger; 180 take children under 18; 420 take healthy volunteers.

This study: 18 Years to 35 Years · male · healthy volunteers too.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 31 studies in Motor Activity by University of Toronto, or all of them as a file.
02

Study summary

The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.

In addition, the secondary objective is to determine the effect of essential amino acids on satellite cell regulation and inflammatory responses during this prolonged recovery period.

03

Conditions studied

  • Healthy

Browse trials for

Keywords

  • exercise
  • recovery
  • muscle
  • protein
04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy, male, recreationally-active participants
  • Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone; Appendix. B). Active will be defined as being in the top 20% of age specific scores on iPAQ (the International Physical Activity Questionnaire; Appendix.C).
  • Participants are required not to engage in lower limb RT (resistance training) for at least 6 months prior to the study.
  • Participants will be 18-35 years old.
  • Participants are willing to abide by the compliance rules of this study

Exclusion criteria

Exclusion Criteria:

  • Female
  • Inability to adhere to any of the compliance rules judged by principle investigator or medical doctor
  • Self-reported regular tobacco use
  • Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
  • The individual who has allergy for milk
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
20 participants (actual)

Study arms

  • Placebo comparator
    Placebo

    4g of maltodextrin

    Dietary Supplement: Placebo

  • Active comparator
    Active

    4g of essential amino acids

    Dietary Supplement: Active

Interventions

  • Dietary supplementActive

    4g of essential amino acids

  • Dietary supplementPlacebo

    4g of maltdextrin

06

What researchers measure

Primary outcomes

  1. Muscle protein synthesis

    Skeletal muscle fractional synthesis rate (%/h) will be determined by oral pulse method using ring-\[D5\]phenylalanine

    Time frame: 4 hours

Secondary outcomes

  1. exercise performance

    Maximal strength (torque in n-M) of the knee extensors will be assessed by a maximal isometric voluntary contraction (MVC).

    Time frame: 4 days

  2. Muscle soreness

    Corresponding subjective ratings of muscle soreness will be collected from participants using a visual analogue scale (mm)

    Time frame: 4 days

  3. Muscle damage

    Muscle damage will be determined by histochemical analysis. muscle damage is defined as Z-band streaming.

    Time frame: 4 days

07

Study locations

1 site
  • Goldring Centre for High Performance Sport
    Toronto, Ontario M5S2C9, Canada
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Oct 2017 to primary completion in Jan 2019, 14 months.

Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's 14 months is below that.

Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 18, 2017
First posted
Oct 24, 2017
StartActual
Oct 18, 2017
Primary completionActual
Jan 15, 2019
CompletionActual
Oct 30, 2019
Last update
Apr 20, 2021
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 20, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03319147
Collaborators
Ajinomoto Co., Inc.
Responsible party
Daniel Moore (Assistant Professor, University of Toronto) — Principal investigator
First posted
Oct 24, 2017
Start date
Oct 18, 2017
Primary completion
Jan 15, 2019
Completion
Oct 30, 2019
Last update
Apr 20, 2021

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion