An interventional study of Whole pea muffins and Split pea muffins in Post-prandial Glycaemic Response and Satiety, sponsored by St. Boniface Hospital. Active, not recruiting at 1 site in Canada. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-11-29.
Sponsored by St. Boniface Hospital · Not applicable, Interventional, and Prevention
This study is part of a group of studies whose overall goal is to accurately define the physiochemical and structural effects of pea varieties and relate these to blood glucose attenuation and appetite related sensations in healthy human volunteers.
A randomized, controlled, cross-over study designed to examine the postprandial glycaemic response and appetite related sensations to peas in muffins will be conducted at the I.H. Asper Clinical Research Institute in Winnipeg, Manitoba. Eligible participants who have provided consent will be asked to attend 4 clinic visits in a fasted state. Participants will be given muffins containing peas at 2 visits and muffins without peas at 2 visits. At each visit participants will provide 7 venous blood samples via indwelling catheter, 7 capillary blood samples via finger poke, 2 urine samples, 5 questionnaires about their appetite and a questionnaire about the acceptability of the products. At the end of each visit, participants will eat pizza ad libitum, and the amount of pizza consumed will be measured to determine if the peas influenced the amount of calories consumed at lunch. Participants will record their food/beverage intake for the rest of the day. Each visit will last approximately 3h and be separated by 3-14 days.
Exclusion Criteria:
2 muffins containing 25g available carbohydrate from whole yellow peas. Intervention: Whole pea muffins
Dietary Supplement: Whole pea muffins
2 muffins containing 25g available carbohydrate from split yellow peas. Intervention: Split pea muffins
Dietary Supplement: Split pea muffins
2 muffins containing 25g available carbohydrate from wheat flour. Intervention: Wheat muffins
Dietary Supplement: Wheat muffins
2 muffins containing wheat flour to match the calories in the whole and split pea muffins. Intervention: Wheat muffins
Dietary Supplement: Wheat muffins
2 muffins containing whole peas
2 muffins containing split peas
2 muffins containing wheat
Post-prandial glucose response
iAUC glucose
Time frame: 120 min
Post-prandial insulin
iAUC insulin
Time frame: 120 min
Appetite ratings
AUC for hunger, fullness, desire to eat and prospective consumption using visual analog scales
Time frame: 120 min
calorie intake
Number of calories consumed post-intervention until bedtime
Time frame: 16 hours
Metabolomics
Metabolite profile in plasma and urine
Time frame: 120 min
Acceptability of test products
Rating of color, aroma, flavor, texture and frequency of eating
Time frame: 15 min
Gastrointestinal side effects
Incidence and duration of GI side effects
Time frame: 24h
Plan to share: Yes — All IPD that underlie results in a publication.
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
This study is active, not recruiting, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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St. Boniface Hospital