An observational study in Hypertension and Pediatric Disorder, sponsored by Wake Forest University Health Sciences. Terminated at 2 sites in United States. Open to participants aged Up to 17 Years. Per ClinicalTrials.gov, last updated 2023-06-12.
Sponsored by Wake Forest University Health Sciences · Observational
Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.
The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements >=90th percentile for age, sex, and height, or >120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.
Subjects that are patients in the Brenner Children's Hospital Pediatric Nephrology Clinic or Emory University Pediatric Nephrology with a confirmed diagnosis of high blood pressure.
Exclusion Criteria:
The cohort of patients seen prior to the implementation of a standardized clinical management protocol on 10/01/2017 whose data is collected retrospectively.
The cohort of patients seen initially seen after implementation of a standardized clinical management protocol on 10/01/2017 whose data is collected prospectively.
Blood pressure
Auscultated blood pressure measurements in clinic
Time frame: 10 years
Left ventricular hypertrophy
Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms
Time frame: 10 years
Albuminuria
Urinary albumin-to-creatinine (\>30 mg/g)
Time frame: 10 years
Ambulatory blood pressure
Ambulatory blood pressure monitoring data
Time frame: 10 years
Renal function
Glomerular filtration rate
Time frame: 10 years
Uric acid
Serum uric acid
Time frame: 10 years
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is terminated, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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Wake Forest University Health Sciences