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CompletedNCT03301337Updated Nov 21, 2022

Amino-acid Uptake After Meat Protein Intake

An interventional study of Meat protein absorption in Amino Acid Metabolism, sponsored by Bispebjerg Hospital. Completed at 1 site in Denmark. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-21.

Sponsored by Bispebjerg Hospital · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
65 Years and older
Sex
All
01

Study summary

The purpose of the project is to provide evidence for the use of hydrolysed meat protein (HMP) as a protein supplement for elderly who has difficulty meeting the recommended daily protein intake.

The study will investigate how the meat protein derived amino acids (from either HMP, steak or minced meat) are absorbed and released into the blood circulation of elderly persons. Hereby, the study will explore the the anabolic potential of HMP compared with common meat products.

02

Conditions studied

  • Amino Acid Metabolism

Keywords

  • Amino acid uptake
  • Aging
  • Meat protein
03

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Healthy
  • Untrained

Exclusion criteria

Exclusion Criteria:

  • below 65 years of age
  • BMI above 30
  • Smokers
  • Vegetarians
  • Subjects with diabetes or other metabolic diseases
  • Medical treatment affecting protein synthesis
  • Gastro-intestinal problems, reduced liver or kidney function, elevated blood pressure, atherosclerosis
  • More than 5 ours regular physical activity per week (except physical activity related to commuting)
04

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Investigator, Outcomes assessor)
Enrollment
12 participants (actual)

Study arms

  • Experimental
    Hydrolyzed meat protein

    D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.

    Dietary Supplement: Meat protein absorption

  • Experimental
    Minced Meat

    D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.

    Dietary Supplement: Meat protein absorption

  • Experimental
    Beef

    D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.

    Dietary Supplement: Meat protein absorption

Interventions

  • Dietary supplementMeat protein absorption

    Meat protein absorption when digested together with a full meal.

05

What researchers measure

Primary outcomes

  1. D5-phenylalanine appearance

    D5-phenylalanine appearance in the blood circulation after meal consumption

    Time frame: 5 hours

Secondary outcomes

  1. Insulin concentration

    Insulin concentration in the blood circulation after meal consumption

    Time frame: 5 hours

06

Study locations

1 site
  • Institute of Sports Medicine Copenhagen
    Copenhagen, DK-2400, Denmark
07

Registry details

Key details

Study ID
NCT03301337
Lead sponsor
Bispebjerg Hospital
Collaborators
DC Ingredients
Responsible party
Jakob Agergaard (Postdoc, PhD, Bispebjerg Hospital) — Principal investigator
First posted
Oct 4, 2017
Start date
Oct 4, 2017
Primary completion
Jan 30, 2018
Completion
Oct 30, 2019
Last update
Nov 21, 2022

Study contacts

Jakob Agergaard, PhD
principal investigator · Institute of Sports Medicine, Copenhagen

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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