An interventional study of Healthy Moves for Aging Well (Healthy Moves) and Active Mind for Aging Well (Active Mind) in Muscle Weakness, sponsored by University of Illinois at Chicago. Completed at 1 site in United States. Open to participants aged 60 Years to 110 Years. Per ClinicalTrials.gov, last updated 2025-06-27.
Sponsored by University of Illinois at Chicago · Not applicable, Interventional, and Prevention
Among 145 studies in Muscle Weakness with a site in United States — 21 open to participants now, 27 under way, none of them phase 3. Muscle Weakness · United States.
Among the 145 studies in Muscle Weakness with a site in United States, this one is the 13th largest by enrollment of the 113 interventional ones that give a count, is one of 12 that started in 2017, is one of 81 with no phase, and was the 58th registered.
477 studies on the registry are indexed under Muscle Weakness; 73 are open to participants now.
Browse Muscle Weakness studies →21 of the 145 studies in Muscle Weakness with a site in United States are open now. Recruiting first, the newest first:
St. Jude Children's Research Hospital · Sites in United States
National Institutes of Health Clinical Center (CC) · Sites in United States
Kansas State University · Sites in United States
University of Florida · Sites in United States
St. Jude Children's Research Hospital · Sites in United States
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 54 Muscle Weakness studies recruiting now, 24 (44%) set no upper age limit and 22 (41%) stop at 75 or younger; 6 take children under 18; 19 take healthy volunteers.
This study: 60 Years to 110 Years · all sexes · no healthy volunteers.
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145 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 10 · Phase 2 17 · Phase 3 2 · Phase 4 6
First in 1995; this study’s year is marked. 12 started in 2017.
This study's enrollment of 157 is above the median of 44 across 362 interventional studies indexed under Muscle Weakness.
Median enrollment 32 across the 113 interventional studies, 73 across the 32 observational. Of the 105 that completed or were terminated, 28 (27%) have results posted.
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22 of 145 have an industry lead sponsor. The 10 most frequent:
University of Illinois at Chicago is the lead sponsor of 506 studies on the registry; 120 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 19 (59%) have results posted.
University of Illinois at Chicago has 1 study filed under Muscle Weakness — fewer than ten, so there is no comparison to draw.
11 of the studies in Muscle Weakness with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05725928The Cleveland ClinicAssisted Ambulation to Improve Health Outcomes for Older Medical Inpatients | 2026-11-30 |
| NCT05877846University of North Carolina, Chapel HillPrecision Medicine and Physical Function | 2026-12-01 |
| NCT07009717University of FloridaRelationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN) | 2026-12-31 |
| NCT06441422Medical College of WisconsinBlood Flow Restriction Training for People With Disabilities | 2026-12-31 |
| NCT00390104Boston Children's HospitalMolecular Analysis of Patients With Neuromuscular Disease | 2026-12-31 |
Among the 145 studies in Muscle Weakness with a site in United States, from their registry updates:
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This study aims to test whether a safe physical activity program with a built-in motivational enhancement component, performed in a seated position, preserves the function and well-being of older home care clients.
Regular physical activity benefits older adults physically and mentally. However, the availability and the evidence for physical activity programs that are safe and appropriate for home-bound older adults at risk for nursing home admission are limited. The current project aims to examine the effectiveness of a safe physical activity program, led by home care aides who regularly help hard-to-reach older home care clients with housekeeping and routine personal care services in the home. The primary aim is to test whether the safe physical activity program with a built-in motivational enhancement component, performed in a seated position, preserves the function and well-being of home care clients. The secondary aim is to understand for whom the program is efficacious, the extent to which the program can reach the target population, the extent to which participants drop out of the program, the extent to which program participants maintain the behavioral change introduced by the intervention, and what the program's cost-effectiveness is. Building on a pilot project that demonstrated the program's feasibility in a large home care program funded by the state and Medicaid, this randomized controlled trial will inform future expansion of the physical activity program into real-world home care settings.
HOME CARE CLIENTS
Inclusion Criteria:
Exclusion Criteria:
HOME CARE AIDES
Inclusion Criteria:
Exclusion Criteria
Home care aides (HCAs) will be trained to deliver Healthy Moves for Aging Well (Healthy Moves), a gentle physical activity program, to their clients. On the first home care visit after the training, HCAs will introduce the program, assess their clients' readiness for the activity and have their clients set personally meaningful goals, and teach the three chair-bound moves. Home care clients will be asked to do the three moves every day. HCAs remind clients of their activity as part of their regular home care visits throughout the 4-month intervention period.
Behavioral: Healthy Moves for Aging Well (Healthy Moves)
Home care aides (HCAs) will be trained to deliver Active Mind for Aging Well (Active Mind), a gentle thinking activity program, to their clients. On the first home care visit after the training, HCAs will introduce the program, assess their clients' readiness for the activity and have their clients set personally meaningful goals, and teach the activity. Home care clients will be asked to do a word search puzzle every day. HCAs remind clients of their activity as part of their regular home care visits throughout the 4-month intervention period.
Behavioral: Active Mind for Aging Well (Active Mind)
A safe physical activity program which consists of a brief motivational enhancement and three movements to be performed in a seated position. The intervention will be delivered by home care aides for their clients.
A word puzzle program which consists of a brief motivational enhancement and word search activities. The intervention will be delivered by home care aides for their clients.
Change from Baseline Function (Daily activity difficulties and dependency in older home care clients) at Month 4
Activities of daily living that are specifically targeted by the intervention (6-items scale; each task will be scored 0-no difficulty/no help; 1=difficulty but no help; 2=need help; summed score, range 0-12)
Time frame: Month 4
Short Physical Performance Battery (SPPB)
Range 0-12 (Guralnik et al., 1994)
Time frame: Baseline, Month 4, Month 8
Exercise-related social support from home care aides
Frequency of support from home care aides. Three items, range 3-9. Adapted from Sallis et al. (1987)
Time frame: Baseline, Month 4, Month 8
Self-rated health
General self-rated health, range 1-5 (poor to excellent)
Time frame: Baseline, Month 4, Month 8
Fear of falling
Short Falls Efficacy Scale-International (FES-I), seven items, 4-point scale (not at all worried to very worried), range 7-28 (Kempen et al., 2008).
Time frame: Baseline, Month 4, Month 8
Basic activities of daily living (secondary outcome)
8-item scale; each task will be scored 0-no difficulty/no help; 1=difficulty but no help; 2=need help, summed score range 0-16 (Gill, Robinson, and Tinetti, 1998)
Time frame: Baseline, Month 4, Month 8
Activities of daily living that are specifically targeted by the intervention (secondary outcome)
6-item scale; each task will be scored 0-no difficulty/no help; 1=difficulty but no help; 2=need help, summed score range 0-12
Time frame: Baseline, Month 4, Month 8
Instrumental activities of daily living (secondary outcome)
4-item scale; each task will be scored 0-no difficulty/no help; 1=difficulty but no help; 2=need help, summed score range 0-8
Time frame: Baseline, Month 4, Month 8
Physical activity levels (secondary outcome)
Days and amount of time spent on three types of physical activity in the past week: strengthening, stretching, and aerobics
Time frame: Baseline, Month 4, Month 8
Falls (secondary outcome)
Number of falls in the past 4 months, and whether any reported falls led to injury that needed medical attention (Yes/No)
Time frame: Baseline, Month 4, Month 8
Ankle range of motion (secondary outcome)
Angle between ankle dorsiflexion and plantarflexion in degrees
Time frame: Baseline, Month 4, Month 8
Pain (secondary outcome)
A scale adapted from SF36 to measure pain, after taking pain medication if applicable, range 0-10
Time frame: Baseline, Month 4, Month 8
Depressive symptoms (secondary outcome)
Feelings in the past week. 9-item scale (Yes/No), range 0-9
Time frame: Baseline, Month 4, Month 8
Plan to share: Yes — After the end of the study, data collection instruments, codebooks, and other data documentation will be made available in conjunction with the dataset in a standard format that is readable across a variety of applications. Guidelines from relevant state agencies and collaborators will be followed.
Supporting information: Study protocol, Statistical analysis plan, Analytic code
Time frame: After the publication of the main study results
Access criteria: To protect participants from re-identification while retaining the analytic utility of the data, the data and associated documentation will be available to users only under a data-sharing agreement, managed by the National Archive of Computerized Data on Aging (NACDA), that provides for: (1) a commitment to using the data only for research purposes and not to identify any individual participant; (2) a commitment to securing the data using appropriate computer technology; and (3) a commitment to destroying or returning the data after analyses are completed. Data will only be released once all Institutional Review Board (IRB) approvals and human subjects concerns have been addressed.
No publications or documents are linked to this record.
Ran from Sep 2017 to primary completion in Dec 2022, 63 months.
Of 200 non-industry interventional studies with no phase under Muscle Weakness, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 28. This study's 63 months is above that.
Counting every sponsor, half of 212 studies reached it within 12 months; a quarter within 5 and three quarters within 28.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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University of Illinois at Chicago →