An observational study in Serrated Polyp, Hyperplastic Polyp and Sessile Serrated Adenoma, sponsored by NYU Langone Health. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-09-29.
Sponsored by NYU Langone Health · Observational
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. A relationship between the human gut microbiota and colorectal cancer has been shown; however, its relationship to the different early precursors of colorectal cancer is understudied. This study tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.
There are no enrollment restrictions based on race or ethnic origins. Vulnerable subjects such as pregnant women and children will not be involved in this study. We will not ask subjects about sensitive topics such as Mental Health, drug/alcohol abuse, or others that fall in this category.
Exclusion Criteria:
Centers for Disease Control and Prevention (CDC) Study of In-home Tests for Colorectal Cancer (SIT)
Diagnostic Test: Mobio PowerSoil DNA Isolation Kit
New York University (NYU) Human Microbiome and Colorectal Tumor study
Diagnostic Test: Mobio PowerSoil DNA Isolation Kit
16S rRNA amplicons covering variable regions V3 to V4 were generated using primers (347F-5'GGAGGCAGCAGTRRGGAAT'-3' and 803R 5'-CTACCRGGGTATCTAATCC-3') incorporating Roche 454 FLX Titanium adapters (Branford, CT) and a sample barcode sequence
Prevalence and relative abundance of selected fecal microbial taxa
Quantitative polymerase chain reaction
Time frame: 2 Days
This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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NYU Langone Health