An observational study in Cushing Disease, sponsored by University Hospital, Brest. Withdrawn. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-26.
Sponsored by University Hospital, Brest · Observational
Cushing's disease is a rare disease that can reduce patients' expectations or quality of life, and for which predictive factors for cardiovascular mortality and recurrence are not well defined.
The primary objective is to determine the rates of remission and recurrence of patients with Cushing's disease diagnosed between 1990 and 2015 in the French region of the West (Angers, Brest, Nantes, Rennes, Poitiers , Tours) focusing on remission particularly at two periods : that after the first pituitary surgery and that on the day of the last news.
The secondary objective is to study the possible prediction of clinical and biological data perioperative of remission and recurrence during follow-up.
Investigators are interested in the prevalence of complications of the pathology (cardiovascular, metabolic, neuropsychological, infectious, rheumatological, etc.) within this cohort, the mortality rate, the rate of remission and recurrence and the quality of life history using the history of patient illness and a questionnaire.
All patients over the age of 18 years at the time of inclusion, formerly or currently being monitored for Cushing's disease diagnosed between January 1, 1990 and December 31, 2015, in one of the six university centers in the West part of France can be included.
All patients over the age of 18 at inclusion, formerly or currently being followed for Cushing's disease diagnosed between 1 January 1990 and 31 December 2015 in one of the six university centers in the French West.
Exclusion Criteria:
Rates de remission and recurrence after the first surgery
rate of postoperative 3-month remission and rate of recurrence after the first surgery
Time frame: between 1 January 1990 and 31 December 2015
predictive factors of remission and recurrence
To study the significance link between the peri-operative clinical and biological characteristics and remission on the one hand and the risk of recurrence after first pituitary surgery on the other hand.
Time frame: between 1 January 1990 and 31 December 2015
No study locations are listed for this record.
This study is withdrawn, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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University Hospital, Brest