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CompletedNCT03286608Updated Sep 18, 2017

Polyphenols and Risk of Dementia

An observational study in Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology, sponsored by Jean-François Dartigues. Completed. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-18.

Sponsored by Jean-François Dartigues · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,329
Ages
65 Years and older
Sex
All
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Study summary

This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12 years following dietary assessment.

Read the detailed description

The study sample includes 1,329 subjects followed for up to 12 years fro dementia after dietary assessment. The aim is to identify a pattern of polyphenol intake (based on 26 flavonoid and non-flavonoid polyphenol subclasses ascertained using a 24-hour dietary recall) associated with the risk of dementia and AD over 12 years in the 3C Bordeaux cohort.

02

Conditions studied

  • Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology
03

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

population of older persons from the community, aged 65 years or more, living in the Bordeaux area (France)

Inclusion criteria

  • 65 years or more, live in Bordeaux area (France)

Exclusion criteria

Exclusion Criteria:

  • with dementia at the time of dietary assessment in year 2001-2002
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,329 participants (actual)
Patient registry
No

Interventions

  • Otherobservational study (no intervention)

    Statistical association between adherence to a pattern of polyphenol intake and the risk to develop dementia and Alzheimer's disease over 12 years

    Also known as: pattern of polyphenol intake

05

What researchers measure

Primary outcomes

  1. incidence of dementia

    incident cases of dementia diagnosed by the expert committee of neurologists at follow-up visits

    Time frame: 12 years

Secondary outcomes

  1. incidence of Alzheimer's disease

    dementia with probable or possible Alzheimer etiology

    Time frame: 12 years

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03286608
Lead sponsor
Jean-François Dartigues
Responsible party
Jean-François Dartigues (Pr, University of Bordeaux) — Sponsor-investigator
First posted
Sep 18, 2017
Start date
Jan 1, 1999
Primary completion
Dec 31, 2015
Completion
Dec 31, 2015
Last update
Sep 18, 2017

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

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