An observational study in Type 2 Diabetes, sponsored by German Diabetes Center. Completed at 1 site in Germany. Open to participants aged 20 Years to 69 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-15.
Sponsored by German Diabetes Center · Observational
G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. Recently, it has been shown that GPR120 expression in human adipose tissue is higher in obese than in lean individuals. Interestingly, a GPR120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (T2D).
Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity.
The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.
Patients with recently diagnosed type 2 diabetes (up to one year from diagnosis) and age- and weight-matched normoglycemic controls
Exclusion Criteria:
Patients with recently diagnosed type 2 diabetes
Age- and BMI-matched normoglycemic subjects
GPR120 expression in adipose tissue
GPR expression is measured in adipose tissue of recently diagnosed type 2 diabetic patients and age- and BMI-matched normoglycemic controls
Time frame: Expression measured at baseline (day 1)
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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German Diabetes Center