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RecruitingNCT01055093GDCUpdated Jul 16, 2025

Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients

An observational study in Diabetes Mellitus, Type 1 and Diabetes Mellitus, Type 2, sponsored by German Diabetes Center. Recruiting at 1 site in Germany. Open to participants aged 18 Years to 69 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-16.

Sponsored by German Diabetes Center · Observational

From the registry’s dates

  • Started Sep 2005; still recruiting 21 years 2 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
2,000
Ages
18 Years to 69 Years
Sex
All
01

Study summary

The aim of the prospective observational GDC-Study in patients with newly diagnosed diabetes mellitus aged 18-69 years at inclusion into the study is to characterize in detail the clinical, metabolical and immunological phenotype and monitor the progression of the disease and to compare the phenotype to glucose tolerant humans of similar age, body mass and sex distribution.

Read the detailed description

In detail, the following questions will be answered:

  1. Are there different phenotypes with respect to insulin secretion, insulin sensitivity, micro- and macrovascular status and diabetic neuropathy at time of diagnosis?
  2. Which factors modify the progression of the disease (Nutrition, subclinical inflammation, energy metabolism and physical activity)?
  3. Can we identify subgroups at baseline with different progression of the disease? Patients are thoroughly examined at baseline and after 2, 5, and 10 years with annual telephone contacts in between.
02

Conditions studied

  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2

Keywords

  • diabetes mellitus
  • prospective observational study
  • diabetic complications
03

In context

Diabetes Mellitus, Type 1

3,754 studies on the registry are indexed under Diabetes Mellitus, Type 1; 600 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 125 across 792 observational studies indexed under Diabetes Mellitus, Type 1.

Browse Diabetes Mellitus, Type 1 studies →

Lead sponsor

German Diabetes Center is the lead sponsor of 30 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 69 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients are recruited from the general populations by screening

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Clinical diagnosis of diabetes mellitus according to ADA criteria
  • Age 18-69
  • Diabetes duration since diagnosis \< 12 months
  • Control cohort: proven normal glucose tolerance according to ADA criteria

Exclusion criteria

Exclusion Criteria:

  • Diabetes mellitus category 3 B-H (ADA criteria)
  • Pregnancy
  • Severe renal, liver or heart disease
  • malignant cancer
  • severe psychiatric illness or addiction
  • participation in an intervention trial
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
2,000 participants (estimated)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Diabetes Cohort

    Prospectively followed cohort of newly diagnosed patients with diabetes mellitus, aged 18-69 years at inclusion into the study

  • Control Cohort

    Prospectively followed cohort of glucose tolerant humans, aged 18-69 years at inclusion into the study

06

What researchers measure

Primary outcomes

  1. Change of insulin sensitivity (M-Value)

    measurement of whole body insulin sensitivity with hyperinsulinamic euglicamic clamp

    Time frame: 2 and 5 years

Secondary outcomes

  1. Change of insulin secretion

    measurement of insulin secretion with glucagon test, mixed-meal test and intravenous glucose tolerance test

    Time frame: 2 and 5 years

  2. Incidence of any diabetic complication

    The prevalence of diabetic complications

    Time frame: 2-10 years

07

Study locations

1 of 1 sites recruiting
  • German Diabetes Center
    Düsseldorf, North Rhine-Westphalia 40225, Germany
    Recruiting
    • Clinical Study Center · Contactstudienzentrum@ddz.de · +49-211-3382-0
    • Michael Roden, Prof., MD · Principal investigator
    • Dan Ziegler, Prof., MD · Sub investigator
    • Christian Herder, PhD, M.Sci. · Sub investigator
    • Wolfgang Rathmann, MD, MSPH · Sub investigator
    • Andrea Icks, MD · Sub investigator
    • Joachim Rosenbauer, Ph.D. · Sub investigator
    • Jörg Kotzka, Ph.D. · Sub investigator
08

References and documents

Publications

  • Szendroedi J, Saxena A, Weber KS, Strassburger K, Herder C, Burkart V, Nowotny B, Icks A, Kuss O, Ziegler D, Al-Hasani H, Mussig K, Roden M; GDS Group. Cohort profile: the German Diabetes Study (GDS). Cardiovasc Diabetol. 2016 Apr 7;15:59. doi: 10.1186/s12933-016-0374-9. PubMed 27053136 ↗
  • Kossler T, Bobrov P, Strassburger K, Kuss O, Zaharia OP, Karusheva Y, Moser C, Bodis K, Burkart V, Roden M, Szendroedi J; GDS Group. Impact of mixed meal tolerance test composition on measures of beta-cell function in type 2 diabetes. Nutr Metab (Lond). 2021 May 4;18(1):47. doi: 10.1186/s12986-021-00556-1. PubMed 33947421 ↗
  • Kupriyanova Y, Zaharia OP, Bobrov P, Karusheva Y, Burkart V, Szendroedi J, Hwang JH, Roden M; GDS group. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus. J Hepatol. 2021 May;74(5):1028-1037. doi: 10.1016/j.jhep.2020.11.030. Epub 2020 Nov 28. PubMed 33259845 ↗
  • Zaharia OP, Strassburger K, Knebel B, Kupriyanova Y, Karusheva Y, Wolkersdorfer M, Bodis K, Markgraf DF, Burkart V, Hwang JH, Kotzka J, Al-Hasani H, Szendroedi J, Roden M; GDS Group. Role of Patatin-Like Phospholipase Domain-Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes. Diabetes Care. 2020 Sep;43(9):2161-2168. doi: 10.2337/dc20-0329. Epub 2020 Jun 19. PubMed 32910776 ↗
  • Maalmi H, Herder C, Strassburger K, Urner S, Jandeleit-Dahm K, Zaharia OP, Karusheva Y, Bongaerts BWC, Rathmann W, Burkart V, Szendroedi J, Roden M. Biomarkers of Inflammation and Glomerular Filtration Rate in Individuals with Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa622. doi: 10.1210/clinem/dgaa622. PubMed 32879938 ↗
  • Kanti G, Anadol-Schmitz E, Bobrov P, Strassburger K, Kahl S, Zaharia OP, Sarabhai T, Karusheva Y, Burkart V, Markgraf DF, Trenkamp S, Ziegler D, Szendroedi J, Roden M; GDS Group. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment. J Clin Endocrinol Metab. 2020 Jun 1;105(6):dgaa150. doi: 10.1210/clinem/dgaa150. PubMed 32219330 ↗
  • Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Mussig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schurmann A, Roden M, Szendroedi J; GDS Study Group. Expansion and Impaired Mitochondrial Efficiency of Deep Subcutaneous Adipose Tissue in Recent-Onset Type 2 Diabetes. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1331-43. doi: 10.1210/clinem/dgz267. PubMed 31838512 ↗
  • Puttgen S, Bonhof GJ, Strom A, Mussig K, Szendroedi J, Roden M, Ziegler D. Augmented Corneal Nerve Fiber Branching in Painful Compared With Painless Diabetic Neuropathy. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6220-6228. doi: 10.1210/jc.2019-01072. PubMed 31390004 ↗
  • Zaharia OP, Strassburger K, Strom A, Bonhof GJ, Karusheva Y, Antoniou S, Bodis K, Markgraf DF, Burkart V, Mussig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Haring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol. 2019 Sep;7(9):684-694. doi: 10.1016/S2213-8587(19)30187-1. Epub 2019 Jul 22. PubMed 31345776 ↗
  • Simon MC, Moller-Horigome A, Strassburger K, Nowotny B, Knebel B, Mussig K, Herder C, Szendroedi J, Roden MW; German Diabetes Study Group. Correlates of Insulin-Stimulated Glucose Disposal in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2019 Jun 1;104(6):2295-2304. doi: 10.1210/jc.2018-02057. PubMed 30689904 ↗
  • Rathmann W, Strassburger K, Bongaerts B, Kuss O, Mussig K, Burkart V, Szendroedi J, Kotzka J, Knebel B, Al-Hasani H, Roden M; GDS Group. A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes. Diabetologia. 2019 Feb;62(2):286-291. doi: 10.1007/s00125-018-4759-z. Epub 2018 Nov 9. PubMed 30413829 ↗
  • Grobosch S, Kuske S, Linnenkamp U, Ernstmann N, Stephan A, Genz J, Begun A, Haastert B, Szendroedi J, Mussig K, Burkart V, Roden M, Icks A; GDS Group. What information needs do people with recently diagnosed diabetes mellitus have and what are the associated factors? A cross-sectional study in Germany. BMJ Open. 2018 Oct 31;8(10):e017895. doi: 10.1136/bmjopen-2017-017895. PubMed 30385437 ↗
  • Schroder K, Szendroedi J, Benthin A, Gontscharuk V, Ackermann P, Volker M, Steingrube N, Nowotny B, Ziegler D, Mussig K, Geerling G, Kuss O, Roden M, Guthoff R; GDS Cohort. German Diabetes Study - Baseline data of retinal layer thickness measured by SD-OCT in early diabetes mellitus. Acta Ophthalmol. 2019 Mar;97(2):e303-e307. doi: 10.1111/aos.13851. Epub 2018 Sep 21. PubMed 30238609 ↗
  • van Gemert T, Wolwer W, Weber KS, Hoyer A, Strassburger K, Bohnau NT, Bruggen MA, Ovelgonne K, Gossmann EM, Burkart V, Szendroedi J, Roden M, Mussig K; GDS Group. Cognitive Function Is Impaired in Patients with Recently Diagnosed Type 2 Diabetes, but Not Type 1 Diabetes. J Diabetes Res. 2018 Aug 9;2018:1470476. doi: 10.1155/2018/1470476. eCollection 2018. PubMed 30159333 ↗
  • Ziegler D, Strom A, Kupriyanova Y, Bierwagen A, Bonhof GJ, Bodis K, Mussig K, Szendroedi J, Bobrov P, Markgraf DF, Hwang JH, Roden M; GDS Group. Association of Lower Cardiovagal Tone and Baroreflex Sensitivity With Higher Liver Fat Content Early in Type 2 Diabetes. J Clin Endocrinol Metab. 2018 Mar 1;103(3):1130-1138. doi: 10.1210/jc.2017-02294. PubMed 29267946 ↗
  • Zaharia OP, Bobrov P, Strassburger K, Bodis K, Karusheva Y, Scholz M, Markgraf DF, Burkart V, Schloot NC, Mussig K, Szendroedi J, Roden M; GDS Group. Metabolic Characteristics of Recently Diagnosed Adult-Onset Autoimmune Diabetes Mellitus. J Clin Endocrinol Metab. 2018 Feb 1;103(2):429-437. doi: 10.1210/jc.2017-01706. PubMed 29220505 ↗
  • Rohling M, Strom A, Bonhof G, Puttgen S, Bodis K, Mussig K, Szendrodi J, Markgraf D, Lehr S, Roden M, Ziegler D; German Diabetes Study Group. Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care. 2017 Feb;40(2):246-252. doi: 10.2337/dc16-1898. Epub 2016 Nov 29. PubMed 27899499 ↗
  • Weber KS, Strassburger K, Pacini G, Nowotny B, Mussig K, Szendroedi J, Herder C, Roden M; German Diabetes Study group. Circulating adiponectin concentration is inversely associated with glucose tolerance and insulin secretion in people with newly diagnosed diabetes. Diabet Med. 2017 Feb;34(2):239-244. doi: 10.1111/dme.13278. Epub 2016 Nov 17. PubMed 27770592 ↗
  • Weber KS, Knebel B, Strassburger K, Kotzka J, Stehle P, Szendroedi J, Mussig K, Buyken AE, Roden M; GDS Group. Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes. Cardiovasc Diabetol. 2016 Sep 27;15(1):138. doi: 10.1186/s12933-016-0455-9. PubMed 27677442 ↗
  • Apostolopoulou M, Strassburger K, Herder C, Knebel B, Kotzka J, Szendroedi J, Roden M; GDS group. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes. Diabetologia. 2016 Oct;59(10):2203-7. doi: 10.1007/s00125-016-4038-9. Epub 2016 Jul 4. PubMed 27376543 ↗
  • Gancheva S, Bierwagen A, Kaul K, Herder C, Nowotny P, Kahl S, Giani G, Klueppelholz B, Knebel B, Begovatz P, Strassburger K, Al-Hasani H, Lundbom J, Szendroedi J, Roden M; German Diabetes Study (GDS) Group. Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes. Diabetes. 2016 Jul;65(7):1849-57. doi: 10.2337/db16-0162. Epub 2016 Apr 19. PubMed 27207512 ↗
  • Knebel B, Strassburger K, Szendroedi J, Kotzka J, Scheer M, Nowotny B, Mussig K, Lehr S, Pacini G, Finner H, Kluppelholz B, Giani G, Al-Hasani H, Roden M; German Diabetes Study Group. Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133. Epub 2016 Feb 1. PubMed 26829444 ↗
  • Weber KS, Nowotny B, Strassburger K, Pacini G, Mussig K, Szendroedi J, Herder C, Roden M; GDS Group. The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and beta-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care. 2015 Sep;38(9):1758-67. doi: 10.2337/dc15-0169. Epub 2015 Jul 7. PubMed 26153272 ↗
  • Menart-Houtermans B, Rutter R, Nowotny B, Rosenbauer J, Koliaki C, Kahl S, Simon MC, Szendroedi J, Schloot NC, Roden M; German Diabetes Study Group. Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: results from the German Diabetes Study (GDS). Diabetes Care. 2014 Aug;37(8):2326-33. doi: 10.2337/dc14-0316. PubMed 25061140 ↗
  • Weber KS, Schlesinger S, Lang A, Goletzke J, Overmohle C, Strathmann EA, Strassburger K, Singh N, Zaharia OP, Trenkamp S, Wagner R, Lieb W, Buyken AE, Roden M, Herder C; GDS group. Differential associations of dietary patterns with estimated 10-year cardiovascular risk in diabetes subtypes. Sci Rep. 2026 Jul 6;16(1):20783. doi: 10.1038/s41598-026-57026-y. PubMed 42409854 ↗
  • Ratter-Rieck JM, Zepina A, Huttasch M, Kupriyanova Y, Petrera A, Trenkamp S, Wagner R, Schrauwen-Hinderling V, Herder C, Roden M; GDS group. Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent-Onset Type 1 Diabetes. Liver Int. 2026 Jun;46(6):e70693. doi: 10.1111/liv.70693. PubMed 42130117 ↗
  • Trinks N, Putzer J, Sutkowski A, Burkart V, Roden M, Kuss O. Comparison of Vyntus CPX and Vmax Encore 29N for indirect calorimetry: a randomised crossover study in participants of the German Diabetes Study with type 2 diabetes. BMJ Open. 2025 Dec 10;15(12):e104761. doi: 10.1136/bmjopen-2025-104761. PubMed 41371739 ↗
  • Jonuscheit M, Korzekwa B, Schar M, Mevenkamp J, Wierichs S, Bobrov P, Sarabhai T, Kahl S, Roden M, Schrauwen-Hinderling VB. 31P-MRS saturation transfer for assessing human hepatic ATP synthesis at clinical field strength. Eur Radiol Exp. 2025 May 13;9(1):51. doi: 10.1186/s41747-025-00588-9. PubMed 40360906 ↗
  • Kaya S, Khamees A, Geerling G, Strzalkowski P, Gontscharuk V, Szendroedi J, Mussig K, Ziegler D, Roden M, Guthoff R; GDS Cohort. Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes. Diabetologia. 2025 Jun;68(6):1140-1156. doi: 10.1007/s00125-025-06407-5. Epub 2025 Mar 31. PubMed 40164944 ↗
  • Kupriyanova Y, Yurchenko I, Bobrov P, Bartels F, Wierichs S, Jonuscheit M, Korzekwa B, Prystupa K, Schon M, Mendez D, Trenkamp S, Burkart V, Wagner R, Schrauwen-Hinderling V, Roden M; German Diabetes Study (GDS) Group. Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes. BMJ Open Diabetes Res Care. 2025 Feb 18;13(1):e004727. doi: 10.1136/bmjdrc-2024-004727. PubMed 39965871 ↗
  • Spagnuolo MC, Gottmann P, Sommer J, Borgmann SO, Strassburger K, Rathmann W, Zaharia OP, Trenkamp S, Wagner R, Icks A, Herder C, Roden M, Maalmi H; GDS Group. Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes. BMJ Open Diabetes Res Care. 2025 Feb 18;13(1):e004396. doi: 10.1136/bmjdrc-2024-004396. PubMed 39965868 ↗
  • Weber KS, Schlesinger S, Goletzke J, Strassburger K, Zaharia OP, Trenkamp S, Wagner R, Lieb W, Buyken AE, Roden M, Herder C; GDS group. Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes. Cardiovasc Diabetol. 2025 Feb 6;24(1):53. doi: 10.1186/s12933-025-02580-4. PubMed 39915806 ↗
  • Weber KS, Schlesinger S, Lang A, Strassburger K, Maalmi H, Zhu A, Zaharia OP, Strom A, Bonhof GJ, Goletzke J, Trenkamp S, Wagner R, Buyken AE, Lieb W, Roden M, Herder C; GDS group. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes. Nutr Metab Cardiovasc Dis. 2024 Apr;34(4):911-924. doi: 10.1016/j.numecd.2023.12.026. Epub 2024 Jan 5. PubMed 38418350 ↗
  • Heilmann G, Trenkamp S, Moser C, Bombrich M, Schon M, Yurchenko I, Strassburger K, Rodriguez MM, Zaharia OP, Burkart V, Wagner R, Roden M. Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes. Clin Chem Lab Med. 2023 Oct 24;62(4):762-769. doi: 10.1515/cclm-2023-0770. Print 2024 Mar 25. PubMed 37870928 ↗
  • Baechle C, Lang A, Strassburger K, Kuss O, Burkart V, Szendroedi J, Mussig K, Weber KS, Schrauwen-Hinderling V, Herder C, Roden M, Schlesinger S; GDS group. Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study. BMJ Open Diabetes Res Care. 2023 Jul;11(4):e003469. doi: 10.1136/bmjdrc-2023-003469. PubMed 37433698 ↗
  • Goletzke J, Weber KS, Kossler T, Zaharia OP, Bodis K, Mussig K, Szendroedi J, Burkart V, Stutz B, Nothlings U, Buyken AE, Roden M; GDS Group. Relative validity of a glycemic index extended food-frequency questionnaire. Nutr Metab Cardiovasc Dis. 2022 Oct;32(10):2310-2320. doi: 10.1016/j.numecd.2022.07.007. Epub 2022 Jul 16. PubMed 35973887 ↗
  • Zaharia OP, Schon M, Loffler L, Strassburger K, Moser C, Yurchenko I, Bodis K, Antoniou S, Karusheva Y, Szendroedi J, Burkart V, Roden M. Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4167-e4176. doi: 10.1210/clinem/dgac480. PubMed 35965389 ↗
  • Bodis K, Knebel B, Nowotny B, Bobrov P, Kupriyanova Y, Zaharia OP, Karusheva Y, Schon M, Wolkersdorfer M, Burkart V, Al-Hasani H, Markgraf D, Mussig K, Roden M, Szendroedi J; GDS study group. Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia. Diabetes Res Clin Pract. 2022 Mar;185:109779. doi: 10.1016/j.diabres.2022.109779. Epub 2022 Feb 14. PubMed 35176401 ↗
  • Saatmann N, Zaharia OP, Strassburger K, Pesta DH, Burkart V, Szendroedi J, Gerdes N, Kelm M, Roden M. Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups. J Clin Endocrinol Metab. 2022 Mar 24;107(4):1127-1139. doi: 10.1210/clinem/dgab810. PubMed 34748634 ↗
  • Pesta D, Jelenik T, Zaharia OP, Bobrov P, Gorgens S, Bodis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Mussig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M. NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes. Front Endocrinol (Lausanne). 2021 Sep 24;12:693683. doi: 10.3389/fendo.2021.693683. eCollection 2021. PubMed 34659107 ↗
  • Zaharia OP, Pesta DH, Bobrov P, Kupriyanova Y, Herder C, Karusheva Y, Bodis K, Bonhof GJ, Knitza J, Simon D, Kleyer A, Hwang JH, Mussig K, Ziegler D, Burkart V, Schett G, Roden M, Szendroedi J. Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis. J Clin Endocrinol Metab. 2021 Mar 25;106(4):1062-1073. doi: 10.1210/clinem/dgaa912. PubMed 33382877 ↗
  • Eckstein ML, Farinha JB, McCarthy O, West DJ, Yardley JE, Bally L, Zueger T, Stettler C, Boff W, Reischak-Oliveira A, Riddell MC, Zaharieva DP, Pieber TR, Muller A, Birnbaumer P, Aziz F, Brugnara L, Haahr H, Zijlstra E, Heise T, Sourij H, Roden M, Hofmann P, Bracken RM, Pesta D, Moser O. Differences in Physiological Responses to Cardiopulmonary Exercise Testing in Adults With and Without Type 1 Diabetes: A Pooled Analysis. Diabetes Care. 2021 Jan;44(1):240-247. doi: 10.2337/dc20-1496. Epub 2020 Nov 12. PubMed 33184152 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 16, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01055093
Lead sponsor
German Diabetes Center
Responsible party
Sponsor
First posted
Jan 25, 2010
Start date
Sep 2005
Primary completion
Sep 2030 (estimated)
Completion
Sep 2040 (estimated)
Last update
Jul 16, 2025

Study contacts

Robert Wagner, Prof., MD
Contact
robert.wagner@ddz.de
+49-211-3382 ext. -277
Petra Heidkamp
Contact
studienzentrum@ddz.de
+49-211-3382 ext. -209
Michael Roden, Prof., MD
principal investigator · German Diabetes Center
View the source record on ClinicalTrials.gov ↗

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