An observational study in Malnutrition, Infant and Malnutrition; Anemia, sponsored by Centre For International Health. Completed at 1 site in Nepal. Open to participants aged 2 Months to 11 Months. Per ClinicalTrials.gov, last updated 2017-09-18.
Sponsored by Centre For International Health · Observational
Between February 2008 and February 2009, 500 infant-mother pairs in Bhaktapur, Nepal were randomly selected in this nutritional survey. The dietary intake, nutritional status of several nutrients, growth, and breastfeeding habits were measured in both the women and their infants.The objective of this first phase was to estimate the intake and status of several nutrients in relation to breastfeeding. These mother-child pairs were revisited around the child's fifth birthday when growth, diet, and neurodevelopment was measured. The objective of this phase was to create a cohort study where factors in infancy could be related with health outcomes and development 5 years later.
Over a period of one year, a total of 500 lactating (encompassing both exclusive and partial breastfeeding) women were enrolled in the study and completed the first 24-hour dietary recall. The women attended a hospital for physical examination, dietary interview, and blood sampling. Blood samples were also collected from their infants who also went through a detailed clinical examination
The blood samples from mothers and infant pairs were collected approximately one week apart. The blood was spun down, plasma separated and transferred into storage vials immediately. Plasma and blood pellets were stored in cryovials at -70 until analysis.
All women were also requested to provide one breast milk and one urine sample.
Plasma, blood pellet, urine, and breast milk was stored at -70 degrees celcius until analysis.
Plasma was analyzed for iron, transferrin receptor, ferritin, cobalamin, folate, vitamin A, vitamin D, vitamin E, several amino acids and other micronutrient related metabolites.
The breast milk will be analyzed for iodine, fatty acids, and several B vitamins
The urine was analyzed for iodine.
In phase 2, after 5 years we revisited the mother-child pairs and measured growth, diet, food security, and neurodevelopment.
67 studies on the registry are indexed under Infant Nutrition Disorders; 14 are open to participants now.
This study's enrollment of 1,000 is above the median of 203 across 20 observational studies indexed under Infant Nutrition Disorders.
Browse Infant Nutrition Disorders studies →Centre For International Health is the lead sponsor of 12 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
A cross-sectional survey was carried out and 500 healthy lactating women (17-44 years old) were randomly selected from Bhaktapur municipality, Nepal. Bhaktapur is an urban area located 15 km east of the capital Kathmandu and was chosen because of the diversity of this population spanning all socio-economic strata, providing a unique opportunity to explore dietary variation.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Prevalence of micronutrient deficiency
The status and prevalence of deficiencies of several micronutrients has been estimated
Time frame: 1 year
Predictors for micronutrient status
We will estimate predictors for several of the measured micronutrients using other biomarkers and clinical and demographic variables.
Time frame: 1 year
Prevalence of anaemia in mothers and children
Hemoglobin concentration is measured for all participants and the proportion anaemic and predictors for anaemia will be presented.
Time frame: 1 year
Neurodevelopment at 5 years
Neurodevelopment is measured when the children are 5 using the Ages and Stages questionnaire and the NEPSY II tests. These measures will be related to micronutrient status, inflammation and stress markers.
Time frame: 5 years
Growth during infancy and at 5 years of age
Growth (length and weight) is measured when the children are 5 years and will be related to nutritional status.
Time frame: 5 years
Markers of stress and inflammation.
Maternal and infants markers of inflammation (CRP, neopterine, kynurenic acid, kynurenine, tryphtophane, etc) and stress (leucocyte telomere length) will be measured and related to micronutrient status.
Time frame: 1 year
Breastmilk b-vitamin concentration
The concentration of several b-vitamins will be estimated in the breast milk and related to dietary intake and maternal and child status
Time frame: 1 year
Plan to share: Undecided — Data can be requested by contacting the principal investigator (Tor Strand) or one of the other investigators.
No publications or documents are linked to this record.
Ran from Jan 2008 to primary completion in Feb 2010, 25 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre For International Health