An observational study in Obesity, Morbid and Pancreatic Insufficiency, sponsored by Umraniye Education and Research Hospital. Status unknown at 1 site in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-09-13.
Sponsored by Umraniye Education and Research Hospital · Observational
Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.
Mechanism of weight loss differs in bariatric surgery according to type of surgery.
With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss.
Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.
Patients who are eligible for bariatric surgery with NIH criteria and American Society of Anesthesiologists (ASA)-Physical Status Classification System.
Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria
Exclusion Criteria:
Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.
Sleeve Gastrectomy will be performed. Preoperative and Postoperative pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.
Procedure: SleeveGastrectomy
Preoperative enzyme test before and after sleeve gastrectomy. Sleeve Gastrectomy will be performed. Preoperative (in one month) and Postoperative (after 3 months) pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.
Pancreatic excorine enzyme difference
Effect of operation on pancreatic excorine enzyme
Time frame: post operative 3 months
Plan to share: No
No publications or documents are linked to this record.
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Exocrine Pancreatic Insufficiency→
Umraniye Education and Research Hospital