CClinicalTrials.gg
CompletedNCT03272113SKIP-ITUpdated Mar 4, 2020

SKIP-IT Smoking Cessation in Pregnancy

An interventional study of SKIP-IT in Smoking Cessation and Pregnancy Related, sponsored by University of Stirling. Completed at 2 sites in United Kingdom. Open to female participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2020-03-04.

Sponsored by University of Stirling · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
16 Years and older
Sex
Female
01

Study summary

The aim of this study is to investigate the feasibility and likelihood of success of a narrative and image-based intervention, administered via text messages, for smoking cessation in pregnant women, prior to undertaking a large scale trial of its effectiveness. A feasibility and pilot trial will be undertaking involving 70 pregnant women who smoke in two NHS Boards.

Read the detailed description

Smoking during pregnancy carries serious risks to mother and infant health. More babies whose mothers smoke are stillborn or die within the first year of life. Smoking during pregnancy results in increased rates of intrauterine growth retardation, preterm birth, and babies' longer-term risk of developing heart disease and diabetes. Pregnant women who smoke are more likely to experience miscarriage, placental abruption, pregnancy-induced hypertension and later conditions such as lung cancer and heart disease.

Reduction in smoking in pregnancy has been a long standing health policy target however there is limited evidence of effectiveness of many smoking cessation interventions and their uptake is generally low. We have developed, and carried out initial testing of an intervention to support smoking cessation in pregnant women using narrative, story-telling delivered via automated text-messages. The intervention aims to alter women's perceptions of risk, social norms, outcomes and self-efficacy using three key elements. 1. a narrative story of a fictional young pregnant woman 'Megan' trying to stop smoking by overcoming a series of commonplace barriers. 2) images showing the size of their fetus and its stage of development 3) an interactive 'help' function to receive a supportive, tailored response. Behaviour change techniques for smoking cessation in pregnancy are embedded in the intervention.

A randomised controlled trial is required to test the effectiveness of the intervention in reducing smoking in pregnancy. The aim of this study is to investigate the feasibility and likelihood of success of the narrative and image-based intervention for smoking cessation in pregnant women. If successful the intervention will be tested in a full-scale (Phase III) multi centre randomised controlled trial.

Objectives:

  1. To assess acceptability and willingness to be randomised to the narrative and image based intervention or usual care.
  2. To assess and compare the feasibility of recruitment strategies, the level of participants' retention in the study and engagement with the intervention.
  3. To assess the acceptability and likely impact of the intervention among pregnant smokers.
  4. To estimate the required sample size for a full trial.
02

Conditions studied

  • Smoking Cessation
  • Pregnancy Related
03

Who can participate

Ages eligible
16 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  1. Women 16 years of age or over,
  2. Live within the catchment areas of study sites,
  3. Up to and including 14 weeks of pregnancy,
  4. Current smoker,
  5. Own or regularly use a mobile phone with media capability,
  6. Understand written English,
  7. Able to give informed consent.

Exclusion criteria

Exclusion Criteria:

  1. Women who do not currently smoke,
  2. Live outside the catchment areas of study sites,
  3. Over 14 weeks of pregnancy,
  4. Do not use or have access to a mobile phone with media capability,
  5. Cannot understand written English,
  6. Not able to give informed consent,
  7. Already enrolled in an alternative formal smoking cessation trial at the time of referral to the study.
04

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
28 participants (actual)

Study arms

  • No intervention
    Control

    Usual care to provided by smoking cessation services in the two study sites. Site one: support from a specialist advisor using motivational interviewing, one to one, group and telephone support. Site two: a smoking cessation incentive scheme administered through community pharmacies. Women who are verified by CO testing to have stopped smoking receive £12.50 per week.

  • Experimental
    Intervention

    Women will receive usual care as described above plus the SKIP-IT intervention

    Behavioral: SKIP-IT

Interventions

  • BehavioralSKIP-IT

    A theory-based intervention using narrative, images and embedded behaviour change techniques, delivered via text-messaging.

05

What researchers measure

Primary outcomes

  1. Recruitment rate

    Progression to a full trial will require recruitment ≥50% of women who give permission to have their details passed to the research team (i.e. those who express initial interest in the study).

    Time frame: 23 months

  2. Drop out rate

    Progression to a full trial will require \<30% dropout

    Time frame: 23 months

  3. Direction of effect

    Progression to a full trial will require direction of effect on smoking cessation rate in favour of the intervention.

    Time frame: 23 months

Secondary outcomes

  1. Engagement

    Engagement in the intervention will be assessed using data captured by the computer system which monitors the text message responses.

    Time frame: 23 months

  2. Acceptability

    Acceptability of the intervention will be assessed in short interviews conducted with intervention group participants at the follow-up points

    Time frame: 23 months

Other outcomes

  1. Smoking cessation outcomes

    1. The Russell Standard abstinence question: if they have smoked at all since the last data collection point (with answers being reported as: 'no, not a puff; 1-5 cigarettes; more than 5 cigarettes'). \[self-reported abstinence\] 2. How many times they have purposefully not smoked for more than 24 hrs since the last data collection time point. \[Self-reported 24hr quit attempts\]

    Time frame: At each subsequent data collection time-point (4 weeks post-randomisation, 36 weeks of pregnancy, 6-7 weeks post due-date, 12-13 weeks post due-date)

06

Study locations

2 sites
  • NHS Ayrshire and Arran
    Ayr, United Kingdom
  • NHS Tayside
    Perth, United Kingdom
07

Registry details

Key details

Study ID
NCT03272113
Lead sponsor
University of Stirling
Collaborators
Glasgow Caledonian University, University of Dundee, University of Southampton, Edinburgh Napier University
Responsible party
Helen Cheyne (Professor of Maternal and Child Health Research, University of Stirling) — Principal investigator
First posted
Sep 5, 2017
Start date
Dec 5, 2017
Primary completion
Oct 16, 2018
Completion
Aug 31, 2019
Last update
Mar 4, 2020

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion