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TerminatedNCT03271996Updated Sep 5, 2017

Fistulectomy vs. Modified Karydakis Procedure for Pilonidal Sinus

An interventional study of Primary closure and Fistulectomy in Pilonidal Sinus, sponsored by Dimitri Christoforidis. Terminated at 1 site in Switzerland. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2017-09-05.

Sponsored by Dimitri Christoforidis · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
16 Years and older
Sex
All
01

Study summary

This study wants to improve patient care affected by pilonidal sinus during and after surgery. Pilonidal sinus excision is a frequent procedure, despite this, there is still not an appropriate surgical technique because of a lack of quality comparative studies.

Read the detailed description

This is a randomized controlled trial. The study will compare the healing of the surgical wound and the recurrence rate after excision and primary para-median closure versus narrow orifice excision (fistulectomy)

Group A: excision and paramedian closure according to modified Karydakis technique

Group B: removal / fistulectomy by scalpels or trephines of primary and drainage orifices, healing of the wound by secondary intention

02

Conditions studied

  • Pilonidal Sinus

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Keywords

  • Pilonidal sinus
  • Bascom
  • Cleft lift
  • Fistulectomy
  • Karydakis
03

Who can participate

Ages eligible
16 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Pilonidal cyst requiring surgery
  • Signed Informed Consent Form

Exclusion criteria

Exclusion Criteria:

  • Abnormal lesions
  • Injuries requiring a closing with rotation flap
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    Primary closure

    Excision of sinus and paramedian closure according to modified Karydakis technique

    Procedure: Primary closure

  • Experimental
    Fistulectomy

    Removal / fistulectomy by scalpels or trephines of primary and drainage orifices and healing of the wound by second intention

    Procedure: Fistulectomy

Interventions

  • ProcedurePrimary closure

    Asymmetric skin incision and total excision of the lesion with monopolar scalpel. Accurate hemostasis, creation of a cutaneous-subcutaneous flap, primary closure with non-absorbable sutures, optional aspiration drainage.

  • ProcedureFistulectomy

    Evaluation of the cavity using a 0.5-1 mm metal probe which will be inserted into the skin orifice. Excision of the skin around the orifice and debridement/excision of the cavity by monopolar scalpel or Trephines

05

What researchers measure

Primary outcomes

  1. Complete healing

    percentage of complete healing

    Time frame: 3 weeks

Secondary outcomes

  1. Time to recovery

    Time to completely recovery

    Time frame: 12 months

  2. percentage of relapse

    percentage of relapse after surgery

    Time frame: 12 months

06

Study locations

1 site
  • Ospedale Regionale di Lugano
    Lugnao, 6900, Switzerland
07

References and documents

Publications

  • Popeskou SG, Pravini B, Panteleimonitis S, Vajana AFDT, Vanoni A, Schmalzbauer M, Posabella A, Christoforidis D. Conservative Sinusectomy vs. excision and primary off-midline closure for pilonidal disease: a randomized controlled trial. Int J Colorectal Dis. 2020 Jul;35(7):1193-1199. doi: 10.1007/s00384-020-03551-9. Epub 2020 Mar 6. Erratum In: Int J Colorectal Dis. 2020 Jul;35(7):1201. doi: 10.1007/s00384-020-03620-z. PubMed 32144531 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03271996
Lead sponsor
Dimitri Christoforidis
Responsible party
Dimitri Christoforidis (Vice-Chief in Surgery, Ente Ospedaliero Cantonale, Bellinzona) — Sponsor-investigator
First posted
Sep 5, 2017
Start date
Apr 2012
Primary completion
Jun 2017
Completion
Jun 2017
Last update
Sep 5, 2017

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

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