An interventional study of Platelet Rich Fibrin Injection and Corticosteroid in Lichen Planus, sponsored by Bezmialem Vakif University. Completed at 1 site in Turkey. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-28.
Sponsored by Bezmialem Vakif University · Not applicable, Interventional, and Treatment
Platelet Rich Fibrine (PRF), which promotes wound healing by supporting angiogenesis, immunity and epithelial proliferation phases. over a decade has since past since PRF was developed and many clinicians now point to the potential use of a liquid version of PRF. a liquid injectable-platelet-rich fibrin (i-PRF) was developed by modifying spin centrifugation forces. At lower centrifugation speeds and by utilizing non-glass centrifugation tubes, the fibrin coagulation could be slowed down at early time points thus generating an injectable PRF. Much like traditional PRF, i-PRF contains an increase in leukocyte number and is further able to stimulate growth factor release.
Lichen planus is a common chronic mucocutaneous inflammatory disorder which generally affect s middle aged adults. Therapeutic methods including topical and systemic corticosteroids for the treatment of oral lichen planus (OLP) are suggested. However, long
-term use of corticosteroids may be associated with local and systemic complications, and moreover, some patients may not be responsive.
The investigators aimed to apply a treatment of autogenous origin (including no foreign products), considering the side effects of our corticosteroids. The study was designed as a split mouth.
The investigators planned to administer I-PRF to one side and intralesional corticosteroid therapy to the other side at patients with bilateral atrophic / erosive oral lichen planus lesions
Lichen planus diagnosis will be made histopathologically. Intraoral photographs and measurements will be taken at the beginning of the treatment and 2 months after the treatment is finished.
Exclusion Criteria:
Intralesional corticosteroid administration
Drug: Corticosteroid
Injectable Platelet rich fibrin
Other: Platelet Rich Fibrin Injection
Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge. I- prf will be injected on one side and corticosteroid will be injected on the other side in patients with bilateral oral lichen planus. Once a week in the first month after treatment and one time at the end of the second month, the patient will be called to the control.
Corticosteroid injection
Visual Analog Scale
Patients were asked to grade the severity of their symptoms in numbers from 1(very mild pain) to 100 (very sever pain) on the visual analog scale in each visit.
Time frame: 6 months
Thongprasom sign scoring system
The lesions were evaluated according to Thongprasom sign scoring system
Time frame: 6 months
Oral Health- Related Quality of Life index (OHIP-14)
Patients were asked to grade the Oral Health- Related Quality of Life index
Time frame: 6 months
Oral Hygiene Index
Oral Hygiene Index were evaluated.
Time frame: 6 months
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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Bezmialem Vakif University