CClinicalTrials.gg
Status unknownNCT03264209Updated Oct 2, 2017

Smart After-Care in Patients With Prostate Cancer

An interventional study of Smart After-Care (Mobile health) in Prostate Cancer, sponsored by Ji Youl Lee. Status unknown at 1 site in Korea, Republic of. Open to male participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2017-10-02.

Sponsored by Ji Youl Lee · Not applicable, Interventional, and Supportive care

The sponsor has not verified this record recently (last verified Sep 2017), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Randomized
Ages
40 Years and older
Sex
Male
01

Study summary

This study aims to examine whether Smart After-Care service (Internet-and mobile-based lifestyle intervention) has an effect on patients' satisfaction and clinical outcomes in patients with prostate cancer on androgen deprivation therapy. Patients with prostate cancer on androgen deprivation therapy will participate in the study. The study design is a randomized controlled trial. The patients were randomly assigned to intervention or usual care groups. Intervention patients received Smart After-Care service for 3 months. Primary endpoint was an increase in patients' physical function as assessed using 2 minute walking test. Secondary endpoints included improvement in muscle strength, short physical performance battery, body composition, and health-related quality of life.

Read the detailed description

After-care is a process targeted towards restoration or maintenance of the physical, mental, intellectual and social abilities of an individual affected by cancer. Internet-and mobile-based lifestyle intervention have emerged as potential modalities to complement and increase accessibility to after-care. In order to meet the growing need for after-care services, we developed a Smart after-care system that will assess the efficacy of a web-based smartphone-enabled intervention. The system provided specialized tools on after-care of prostate cancer including information on nutrition, physical activity, medication adherence, and mobile device that can connect to the smartphone. Patients with prostate cancer on androgen deprivation therapy will be screened for having adequate musculoskeletal and cardiopulmonary function.The study design is a randomized controlled trial. The patients were randomly assigned to intervention or usual care groups. Intervention patients received Smart After-Care management for 3 months. Primary endpoint was an increase in patients' physical function as assessed using 2 minute walking test. Secondary endpoints included improvement in muscle strength, short physical performance battery, body composition, and health-related quality of life.

02

Conditions studied

  • Prostate Cancer

Browse trials for

03

Who can participate

Ages eligible
40 Years and older
Sexes eligible
Male
Accepts healthy volunteers
No

Inclusion criteria

  • Males diagnosed with prostate cancer
  • Current treatment with ADT (GnRH agonist/antagonist with or without antiandrogen) for a minimum of 6 months after randomization
  • Having Android smartphone

Exclusion criteria

Exclusion Criteria:

  • Having another (active) malignant disease within 3 month before randomization
  • Having severe cardiopulmonary disease
  • Having bone pain due to bone metastasis, (or) pathologic fracture
  • Receiving total knee replacement arthroplasty, (or) total hip replacement arthroplasty
  • No permission from treating/study physician to participate in exercise
04

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
200 participants (estimated)

Study arms

  • Experimental
    Intervention: Case management

    Case management consists confirmation of hospital visit date, checking the efficacy of intervention, adverse effect and treatment compliance

    Behavioral: Smart After-Care (Mobile health)

  • No intervention
    Control: usual care

    Usual care is provided with life style intervention including exercise and nutrition by printed materials.

Interventions

  • BehavioralSmart After-Care (Mobile health)

    Patients in intervention group will be provided with Smart After-Care Service including intervention for physical activity (aerobic exercise at least 90 or 150 minutes every week for 12 weeks depending on patients' aerobic fitness by monitoring with smartband and strengthening exercise at least 2 times a week for 12 weeks), information for prostate cancer and adequate life style, and smartband that can connect to the smartphone. Case management consists confirmation of hospital visit date, checking the adverse effect and treatment compliance.

05

What researchers measure

Primary outcomes

  1. Physical function (2 minute walking test)

    Cardiorespiratory endurance was examined by 2MWT performed on a 15.2-m hallway out-and-back course. Patients were instructed to walk as fast as they could until asked to stop at 2 min; the distance covered was recorded.

    Time frame: 3 months after randomization

Secondary outcomes

  1. Changes in muscle strength

    A handgrip strength test was used to assess upper extremity muscle strength using a hand-held dynamometer. Patients were instructed to apply maximal power for 3 s with the shoulder adducted and neutrally rotated, elbow flexed at 90°, and the forearm and wrist in a neutral position. Three attempts were given with each hand and the best score (kg) for each was recorded. A 30-s chair stand test was used as a measure of lower extremity muscle strength. Each patient was seated in the middle of the chair (seat height of 40 cm, without armrests but with a backrest) with their back straight and both arms folded across their chest. The patients were instructed to stand up and sit down repetitively and encouraged to complete as many full stands as possible for 30 s while the instructor kept count.

    Time frame: 3 months after randomization

  2. Changes in short physical performance battery

    The SPPB is calculated from three components: the ability to stand for up to 10 seconds with feet positioned in three ways (together side-by-side, semi-tandem and tandem); time to complete a 3-m or 4-m walk; and time to rise from a chair five times.

    Time frame: 3 months after randomization

  3. Changes in body composition

    weight in kilograms, height in meters, body fat mass in kilograms, skeletal muscle mass in kilograms

    Time frame: 3 months after randomization

  4. Changes in health-related quality of life by EORTC QLQ-C30

    Units on a Scale

    Time frame: 3 months after randomization

  5. Changes in health-related quality of life by EORTC QLQ-PR25.

    Units on a Scale

    Time frame: 3 months after randomization

06

Study locations

1 of 1 sites recruiting
07

Registry details

Key details

Study ID
NCT03264209
Lead sponsor
Ji Youl Lee
Responsible party
Ji Youl Lee (professor, Seoul St. Mary's Hospital) — Sponsor-investigator
First posted
Aug 29, 2017
Start date
Sep 11, 2017
Primary completion
Aug 2018 (estimated)
Completion
Dec 2018 (estimated)
Last update
Oct 2, 2017

Study contacts

Yong Hyun Park, MD, PhD
Contact
lestat04@catholic.ac.kr
82-2-2258-6076
Ji Youl Lee, MD, PhD
principal investigator · Seoul St. Mary's Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion