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CompletedNCT03262025Updated Aug 25, 2017

Primary Cecal Pathologies Presenting as Acute Abdomen

An observational study in Acute Abdomen, Emergency Surgery and Laparotomy, sponsored by Jawaharlal Nehru Medical College. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-25.

Sponsored by Jawaharlal Nehru Medical College · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
43
Ages
18 Years and older
Sex
All
01

Study summary

Background: The importance of cecal pathologies lie in the fact that being the first part of large intestine, any disease involving the cecum affects overall functioning of the large bowel. Primary cecal pathologies presenting as acute abdomen have not been described in any previous study in terms of presentation, management and outcome.

Objectives: The objective of this study was to identify the reported causes of primary cecal pathologies presenting as acute abdomen and the various causes presenting in Indian setting, to discuss morbidity and mortality associated with cecal pathologies and to critically analyse the various management modalities employed in emergency setting.

Read the detailed description

The importance of cecal pathologies lie in the fact that being the first part of large intestine, any disease involving the cecum affects overall functioning of the large bowel. Primary cecal pathologies presenting as acute abdomen often pose a challenge to their optimal management due to requirement of urgent intervention in most cases and being a common source of misdiagnosis. These pathologies often mimic acute appendicitis and commonly misdiagnosed as one. This misdiagnosis can lead to under-treatment of the underlying pathology and this results in high morbidity and mortality associated with these conditions. So the accurate identification of such conditions is required so that the patients can be optimally managed and patient outcome can be improved.

02

Conditions studied

  • Acute Abdomen
  • Emergency Surgery
  • Laparotomy
  • Amoebic Colitis
  • Diverticulitis of Caecum
  • Typhlitis

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Keywords

  • Primary cecal pathology
  • Emergency laparotomy
  • Ruptured liver abscess
  • Right hemicolectomy
  • Conservative colonic resection
  • Fulminant amoebic colitis
  • Ileocecal resection
  • Ileoascending anastomosis
  • Ileotransverse anastomosis
  • Cecal diverticulitis
  • Amoebic typhilitis
  • Idiopathic typhilitis
03

In context

Abdomen, Acute

65 studies on the registry are indexed under Abdomen, Acute; 14 are open to participants now.

This study's enrollment of 43 is below the median of 233 across 36 observational studies indexed under Abdomen, Acute.

Browse Abdomen, Acute studies →

Lead sponsor

Jawaharlal Nehru Medical College is the lead sponsor of 5 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All adult patients presenting in the emergency department with acute abdomen were included in study in whom cecal pathology as the cause of acute abdomen was suspected clinically and/or on imaging and further confirmed per-operatively and/or on histopathological examination (HPE) or on imaging.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All adult patients presenting in emergency department with acute abdomen were included in study in whom cecal pathology as the cause of acute abdomen was suspected clinically and/or on imaging and further confirmed per-operatively and/or on histopathological examination (HPE) or on imaging. Patients identified with primarily a cecal pathology who had acute pain abdomen as the initial symptom but who didn't presented immediately due to various reasons were also included in the study as it is a well-documented fact that patients in developing countries like India, especially those who live in rural areas or who are illiterate often resort to indigenous methods of treatment or take symptomatic treatment from local practitioners before presenting to a tertiary centre for definitive treatment. Also, only those patients who were operated within 24 hours of index admission in the emergency operation theatre (EOT) by a registrar or faculty member after initial resuscitation were included in the study.

Exclusion criteria

Exclusion Criteria:

  • Patients with sub-acute, intermittent or chronic pain; when predominant symptoms were attributable to some other cause even with concomitant presence of a cecal pathology; when predominant pathology was not cecal and patients with cecal pathology operated as an elective case were excluded from this study. Thus patients diagnosed to be having appendiceal stump blowout, perforation of base of appendix, ileocecal tuberculosis or intussusception were not included.
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
43 participants (actual)
Patient registry
No

Groups and cohorts

  • Operated patients who survived

    Patients who were discharged in index hospital admission after operative intervention

    Procedure: Operated

  • Operated patients who expired

    Patients who expired in index hospital admission after operative intervention

    Procedure: Operated

  • Non-operated patients who survived

    Patients who were discharged in index hospital admission after being managed conservatively

  • Non-operated patients who expired

    Patients who expired in index hospital admission after being managed conservatively

Interventions

  • ProcedureOperated

    Patients were either managed conservatively or underwent emergency laparotomy

06

What researchers measure

Primary outcomes

  1. Pattern of primary cecal pathology in Indian setting

    The objective of this study was to identify the reported causes of cecal pathology presenting as acute abdomen in medical literature and the various causes presenting in Indian setting, to identify the pattern of common pathologies in Indian setup, to discuss morbidity and mortality associated with cecal pathologies and to critically analyse the various management modalities commonly employed for cecal pathologies presenting as acute abdomen.

    Time frame: 10 years

07

Study locations

No study locations are listed for this record.

08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: Undecided — Data can be shared on request for multi-institutional prospective studies.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2016 to primary completion in May 2017, 16 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 23, 2017
First posted
Aug 25, 2017
StartActual
Jan 1, 2016
Primary completionActual
May 31, 2017
CompletionActual
Jul 15, 2017
Last update
Aug 25, 2017
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 25, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03262025
Lead sponsor
Jawaharlal Nehru Medical College
Responsible party
Kaushal Deep Singh (Principal Investigator, Jawaharlal Nehru Medical College) — Principal investigator
First posted
Aug 25, 2017
Start date
Jan 1, 2016
Primary completion
May 31, 2017
Completion
Jul 15, 2017
Last update
Aug 25, 2017

Study contacts

Kaushal D Singh, MS Surgery
principal investigator · Jawaharlal Nehru Medical College, Aligarh

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.

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