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RecruitingNCT07587190Updated May 14, 2026

Effectiveness of Implementing the Adapted Practice Guidelines for Primary Care of Acute Abdomen in Zambia: An Effectiveness-Implementation Hybrid Type 2 Study Design.

An interventional study of Practice guidelines for primary care of acute abdomen and No intervention in Practice Guidelines for Primary Care of Acute Abdomen, sponsored by University of Bergen. Recruiting at 1 site in Zambia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-14.

Sponsored by University of Bergen · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Registered 8 months after the study started (first participant enrolled Sep 2025, registered May 2026).
  • Started Sep 2025; still recruiting 1 year 2 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
280
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The study aims 1) to adapt, 2) to develop implementation strategies for and 3) to evaluate the effect of implementing a practice guideline for acute abdomen at primary care level in Zambia. We employ a sequential exploratory mixed method study design. Qualitative and quantitative data from health care workers will be used to adapt a practice guideline developed in a high-income into a low- and middle-income (LMIC) context and to develop strategies for successful implementation. The primary outcome of interest is the prospective change in length of stay in hospital among patients presenting with acute abdomen in the intervention site compared to the control site. The study will address the scarcity of literature on practice guidelines for acute abdomen in the LMIC context. The implementation of an adapted guideline may contribute to a reduction of the morbidity and mortality rates associated with acute abdomen in this setting by increasing management capacity at the primary care level.

02

Conditions studied

  • Practice Guidelines for Primary Care of Acute Abdomen

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Keywords

  • Acute Abdomen, Practice guidelines, Primary Health Care, Adaptation, Implementation Strategies, Effectiveness-Implementation Hybrid Type 2 Study Design
03

In context

Abdomen, Acute

65 studies on the registry are indexed under Abdomen, Acute; 14 are open to participants now.

This study's planned enrollment of 280 is above the median of 188 across 26 interventional studies indexed under Abdomen, Acute.

Browse Abdomen, Acute studies →

Lead sponsor

University of Bergen is the lead sponsor of 143 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Data from all patients 18 year and older with acute abdomen including surgical, gynecological and medical acute abdomen managed at the intervention site and control site will be collected during the study period.

Exclusion criteria

Exclusion Criteria:

  • All cases of acute abdomen secondary to trauma will be excluded from the study. All patients in the immediate postoperative phase operated from other facilities presenting with acute abdomen.
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
280 participants (estimated)

Study arms

  • Experimental
    Intervention site

    The intervention site will have the guidelines for acute abdomen implemented

    Other: Practice guidelines for primary care of acute abdomen

  • Active comparator
    Control site

    The control site will not have the guidelines implemented

    Other: No intervention

Interventions

  • OtherPractice guidelines for primary care of acute abdomen

    Adjusted practice guidelines for primary care of acute abdomen will be implemented at the intervention site.

  • OtherNo intervention

    The control site will receive no intervention.

06

What researchers measure

Primary outcomes

  1. Length of Hospital Stay

    The duration of time in days that a patient with acute abdomen stays in the hospital from the day of admission to discharge

    Time frame: 7 days

07

Study locations

1 of 1 sites recruiting
  • Kanyama First Level Hospital and Matero First Level Hospital
    Lusaka, Lusaka Province 10101, Zambia
    Recruiting
08

References and documents

Individual participant data

Plan to share: Yes

Supporting information: Study protocol

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07587190
Collaborators
University of Zambia
Responsible party
Sponsor
First posted
May 14, 2026
Start date
Sep 1, 2025
Primary completion
Aug 31, 2026 (estimated)
Completion
Dec 31, 2028 (estimated)
Last update
May 14, 2026

Study contacts

Wilson Mbewe, MD
Contact
wimbe8573@uib.no
+260977466316
Elisabeth Marie Strømme, MD, PhD
study director · University of Bergen
Thomas Mildestvedt, MD, PhD
study director · University of Bergen
Eivind Meland
study director · University of Bergen
Mpundu Makasa
study director · University of Zambia

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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