CClinicalTrials.gg
CompletedNCT03259321Updated Mar 15, 2024

Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes

An observational study in Type2 Diabetes, sponsored by Zhejiang University. Completed. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-03-15.

Sponsored by Zhejiang University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
15,100
Ages
20 Years and older
Sex
All
01

Study summary

The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of type 2 diabetes (T2D) is heavily debated but evidence from large populations in China is scant. The investigators aim to use data from the China Health and Nutrition Survey (CHNS) to assess the long-term association between fish, PUFA intake and T2D risk.

Read the detailed description

The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of T2D is heavily debated but evidence from large populations in China is still lacking. The investigators aim to utilize data from China Health and Nutrition Survey (CHNS, 1997-2011). The investigators will calculate cumulative means of fish and PUFA intake based on 3-day food records in each wave. Sex-specific Cox regression models will be used to estimate relative risk of T2D. Results from this work will provide epidemiological evidence for improving recommendations on fish and PUFA intake for Chinese in dietary guidelines.

02

Conditions studied

  • Type2 Diabetes

Keywords

  • Fish
  • Polyunsaturated fatty acids
  • CHNS
03

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.

Inclusion criteria

  • Adults aged ≥20 with complete data on diet and follow-up time

Exclusion criteria

Exclusion Criteria:

  • Missing information for Type 2 diabetes
  • Type 2 diabetes
  • Cardiovascular disease
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
15,100 participants (actual)
Patient registry
No
05

What researchers measure

Primary outcomes

  1. Type 2 diabetes

    Incidence of type 2 diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%

    Time frame: From entry into the study (baseline: 1997-2009) until 2011

Secondary outcomes

  1. Fish and polyunsaturated fatty acids intake

    Cumulative averages of fish and PUFA intake based on 3-day 24-hr recall in each wave

    Time frame: From entry into the study (baseline: 1997-2009) until 2011

06

Study locations

No study locations are listed for this record.

07

References and documents

Publications

  • Zhuang P, Mao L, Wu F, Wang J, Jiao J, Zhang Y. Cooking Oil Consumption Is Positively Associated with Risk of Type 2 Diabetes in a Chinese Nationwide Cohort Study. J Nutr. 2020 Jul 1;150(7):1799-1807. doi: 10.1093/jn/nxaa103. Erratum In: J Nutr. 2020 Sep 1;150(9):2490. doi: 10.1093/jn/nxaa242. PubMed 32364230 ↗
  • Wu F, Mao L, Zhuang P, Chen X, Jiao J, Zhang Y. Plant-sourced cooking oil consumption is associated with lower total mortality in a longitudinal nationwide cohort study. Clin Nutr. 2020 Dec;39(12):3703-3710. doi: 10.1016/j.clnu.2020.03.031. Epub 2020 Apr 2. PubMed 32359931 ↗
  • Zhuang P, Shou Q, Wang W, He L, Wang J, Chen J, Zhang Y, Jiao J. Essential Fatty Acids Linoleic Acid and alpha-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity. Mol Nutr Food Res. 2018 Sep;62(17):e1800448. doi: 10.1002/mnfr.201800448. Epub 2018 Aug 12. PubMed 29935107 ↗
08

Registry details

Key details

Study ID
NCT03259321
Lead sponsor
Zhejiang University
Collaborators
National Institute of Health and Nutrition
Responsible party
Jingjing Jiao (Associate Professor, Zhejiang University) — Principal investigator
First posted
Aug 23, 2017
Start date
Jan 1, 1989
Primary completion
Dec 31, 2011
Completion
Dec 31, 2012
Last update
Mar 15, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion