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CompletedNCT03258268EASY-1Updated Oct 5, 2020

Easy Diabetes Treatment Study 1

An interventional study of Standard of Care with EASY DSS and Standard of Care without EASY DSS in Type 2 Diabetes Mellitus, sponsored by Läkarexpressen AB. Completed at 3 sites in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-10-05.

Sponsored by Läkarexpressen AB · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
311
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

A 26-week, multicenter, parallel two-arm, randomized controlled trial of the glycemic outcomes of individualized treatment support in patients with type 2 diabetes. The primary objective of the trial is to confirm the superiority of standard of care with EASY DSS versus standard of care without EASY DSS in terms of glycemic control in patients with type 2 diabetes with ongoing treatment with any antidiabetic drug(s).

02

Conditions studied

  • Type 2 Diabetes Mellitus
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial
  • ≥ 18 years of age at the time of signing informed consent
  • Type 2 diabetes (diagnosed clinically) ≥ 6 months prior to screening
  • HbA1c ≥ 7.0 [58 mmol/mol] by central laboratory analysis
  • Stable daily treatment with any single antidiabetic drug or any combination of antidiabetic drugs for at least 90 days prior to screening (dose adjustment ±10% of insulin dose and temporary dose correction because of e.g. infection are allowed)

Exclusion criteria

Exclusion Criteria:

  • Previous participation in this trial. Participation is defined as informed consent.
  • Currently participating in other clinical trials for diabetes
  • Type 1 diabetes diagnosed clinically and/or by the presence of diabetes-associated autoantibodies
  • History of diabetic ketoacidosis or hyperosmolar hyperglycemic state
  • Corticosteroid-induced or pancreatitis-induced diabetes
  • History of chronic or acute pancreatitis
  • Known or suspected substance abuse
  • Pregnancy
  • Anticipated change in concomitant medication, which, in the opinion of the investigator, could interfere with the glucose metabolism (e.g. systemic corticosteroids or statins)
  • Uncontrolled hypertension (systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 100 mmHg)
  • Renal failure stage 5, defined as (estimated or exact) glomerular filtration rate \< 15 mL/min/1.73m2
  • Recent or planned major surgery (such as gastric bypass operation)
  • Major psychiatric disorders, mental incapacity, unwillingness or language barrier precluding adequate understanding of the trial procedure or cooperation with the trial site personnel
  • Life-threatening disease including malignant neoplasms and medical history of malignant neoplasms within the last 5 years (except basal and squamous cell skin cancer)
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
311 participants (actual)

Study arms

  • Experimental
    Standard of Care with DSS

    Patients will receive standard of care with a board certified physician with EASY DSS. The choice of treatment will be made by the investigator. In the investigational arm this will be based on the clinical judgment of the investigator supplemented with support from the EASY DSS and in the control arm this will be based on the clinical judgment of the investigator alone.

    Device: Standard of Care with EASY DSS

  • Active comparator
    Standard of Care without DSS

    Patients will receive standard of care with a board certified physician without EASY DSS. The choice of treatment will be made by the investigator. In the investigational arm this will be based on the clinical judgment of the investigator supplemented with support from the EASY DSS and in the control arm this will be based on the clinical judgment of the investigator alone.

    Other: Standard of Care without EASY DSS

Interventions

  • DeviceStandard of Care with EASY DSS

    The EASY DSS is a software tool designed to process and analyze data to facilitate individualized treatment suggestions for type 2 diabetes patients. Patients will receive standard of care with a board certified physician with EASY DSS. The choice of treatment will be made by the investigator. In the investigational arm this will be based on the clinical judgment of the investigator supplemented with support from the EASY DSS and in the control arm this will be based on the clinical judgment of the investigator alone.

  • OtherStandard of Care without EASY DSS

    Patients will receive standard of care with a board certified physician without EASY DSS. The choice of treatment will be made by the investigator. In the investigational arm this will be based on the clinical judgment of the investigator supplemented with support from the EASY DSS and in the control arm this will be based on the clinical judgment of the investigator alone.

05

What researchers measure

Primary outcomes

  1. HbA1c

    Change from baseline HbA1c

    Time frame: 26 weeks

Secondary outcomes

  1. Fasting plasma glucose

    Change from baseline in fasting plasma glucose (FPG)

    Time frame: 26 weeks

  2. Achieving treatment target

    Meeting treatment target of HbA1c \< 7% (53 mmol/mol)

    Time frame: 26 weeks

  3. Hypoglycemia

    Meeting treatment target of HbA1c \< 7% (53 mmol/mol) without severe or clinically significant hypoglycemic episodes

    Time frame: 26 weeks

06

Study locations

3 sites
  • Region Halland
    Halland, Sweden
  • Region Skåne
    Skåne, Sweden
  • Västra Götalandsregionen
    Västra Götaland, Sweden
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03258268
Lead sponsor
Läkarexpressen AB
Collaborators
Region Skane, Lund University, Region Halland, Västra Götalandsregionen
Responsible party
Sponsor
First posted
Aug 23, 2017
Start date
Aug 7, 2017
Primary completion
Dec 12, 2019
Completion
Dec 19, 2019
Last update
Oct 5, 2020

Study contacts

Damon Tojjar, MD
principal investigator · Lund University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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