An observational study in Overweight and Obesity, sponsored by University of California, San Diego. Completed at 1 site in United States. Open to participants aged 8 Years to 11 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-29.
Sponsored by University of California, San Diego · Observational
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of learning using fMRI.
The primary aim of this project is to conduct an adequately powered study that compares children at low risk for obesity to children at high risk for obesity on their brain responses to food tastes during a pavlovian learning task. Seven assessment visits will be conducted at three separate time points; baseline, 1-year follow up, and 2-year follow up. Assessments will include anthropometry, interviews, computer tasks, questionnaires, and an fMRI scan. This program of research tests a novel hypothesis regarding overeating and the development of obesity in children, and could provide critical data on individual vulnerabilities to overeating for further research. Furthermore, this study could provide mechanisms for intervention with regards to cue-reward learning in children, to ultimately prevent obesity in youth.
Healthy-weight children (5-75thBMI%) between the ages of 8 and 11 years old with either two over-weight parents (BMI>25) or two healthy-weight parents (BMI = 18-24.9)
Exclusion Criteria:
Healthy-weight children (5th-75thBMI%) with two overweight/obese parents (BMI\>25)
Other: Functional MRI
Healthy-weight children (5th-75thBMI%) with two healthy-weight parents (BMI = 18-24.9)
Other: Functional MRI
Cue-reward learning
Whether rate of the shift in BOLD response from food cue to neutral cue is different between high and low-risk children
Time frame: Baseline only
Reward Sensitivity
Whether the BOLD response to food cue differs between high and low-risk children
Time frame: Baseline only
Weight gain
Whether rate of cue reward and reward sensitivity predict weight gain
Time frame: Change from baseline at an average of 12 months and 24 months
Plan to share: Undecided
This study is completed, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.
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University of California, San Diego