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Status unknownNCT03252080Updated Aug 17, 2017

Effect of Holistic Management on the Patients With Type 2 Diabetes

An interventional study of short-term intensive education and Holistic management in Type 2 Diabetes Mellitus, sponsored by Cheng Qing-feng. Status unknown. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2017-08-17.

Sponsored by Cheng Qing-feng · Not applicable, Interventional, and Supportive care

The sponsor has not verified this record recently (last verified Aug 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
All
01

Study summary

Two hundreds patients with T2DM from the outpatient clinic of The First Affiliated Hospital of Chongqing Medical University will be enrolled in this study. Participating subjects will be randomly assigned into one of the 2 groups: Group A (n=100) will be placed on the short-term intensive education program alone while Group B (n=100) will be placed on the short-term intensive education as well as a holistic management for 6 months.

Diabetes education: The patients of each group will undergo designated education programs in 4 subgroups. Group A and B will be given the same education classes once a week in the first month (total 4 times), 5 hours per class. The education classes will be taught by a dedicated team of diabetes specialist doctors and nurses, with the contents including a basic understanding of diabetes, diabetic diet, exercise, drug treatments and blood glucose monitoring. At the conclusion of the education classes, the patients in Group B then will undergo a weekly telephone interview with specialist nurses for 6 months to help patients resolve self-management problems while patients in Group A will not. The specialist nurses will talk individually with the patients in Group B for 10-15 min per week. The nurses will ask the patients about their results of self-blood glucose monitoring, help them find the reasons of poor blood glucose control as well as answer the patient's questions.

Clinical examination: All subjects will complete Audit of Diabetes Dependent Quality of Life (ADDQoL) before education classes commence (baseline), at 3 months and 6 months (endpoint) after education classes to evaluate their quality of life. All patients will be examined for height, weight, blood pressure, FPG, PPG and HbA1c at baseline, 3 months after education classes and endpoint. A diabetes specialist nurse will measure the height, weight and blood pressure, and assist the subjects to fill the questionnaire. FPG and PPG will be determined by the hexokinase method, while HbA1c by high performance liquid chromatography.

02

Conditions studied

  • Type 2 Diabetes Mellitus

Keywords

  • type 2 diabetes
  • holistic management
03

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with T2DM for more than 1 year,
  • Age from 18 to 75 years old,
  • Have fasting plasma glucose (FPG) ≥ 7.2mmol/L or 2 hours postprandial plasma glucose (2hPPG) ≥ 10.0mmol/L,
  • Glycosylated hemoglobin (HbA1c) ≥ 7.0%,
  • Have the ability to self-care.

Exclusion criteria

Exclusion Criteria:

  • Patients with severe liver or kidney dysfunction, severe heart failure, cognitive dysfunction or pregnancy will be excluded.
04

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
200 participants (estimated)

Study arms

  • Active comparator
    Education (Group A)

    short-intensive education for one month

    Behavioral: short-term intensive education

  • Experimental
    Education & holistic management(Group B)

    short-intensive education for one month followed with holistic management for 6 months

    Behavioral: short-term intensive education · Behavioral: Holistic management

Interventions

  • Behavioralshort-term intensive education

    The patients of both groups are given the education classes once a week in the first month (total 4 times), 5 hours per class. The education classes are taught by a dedicated team of diabetes specialist doctors and nurses, with the contents including a basic understanding of diabetes, diabetic diet, exercise, drug treatments and blood glucose monitoring.

  • BehavioralHolistic management

    The specialist nurses talk individually with the patients for 10-15 min per week. The nurses ask the patients about their results of self-blood glucose monitoring, help them find the reasons of poor blood glucose control as well as answer the patient's questions.

05

What researchers measure

Primary outcomes

  1. ADDQoL score at endpoint

    All subjects complete Audit of Diabetes Dependent Quality of Life (ADDQoL) at endpoint to evaluate their quality of life. There are 13 items including Employment/career, Social life, Family relationships, Friends, Sex life, Sport/leisure, Travel, Future (own), Future of family, Motivation, Physical activities, Others fussing and Enjoyment of food. Each item is scored -3 to +3 (-3 = would be a great deal better if I did not have diabetes; +3 = would be a great deal worse if I did not have diabetes), yielding total between -39 to +39.

    Time frame: 6 months

Secondary outcomes

  1. Change of ADDQoL score between baseline and endpoint

    All subjects complete Audit of Diabetes Dependent Quality of Life (ADDQoL) at baseline and endpoint to evaluate their quality of life. There are 13 items including Employment/career, Social life, Family relationships, Friends, Sex life, Sport/leisure, Travel, Future (own), Future of family, Motivation, Physical activities, Others fussing and Enjoyment of food. Each item is scored -3 to +3 (-3 = would be a great deal better if I did not have diabetes; +3 = would be a great deal worse if I did not have diabetes), yielding total between -39 to +39. The change of ADDQoL score between baseline and endpoint = the total score of ADDQoL at endpoint - the total score of ADDQoL at baseline.

    Time frame: 6 months

  2. FPG at endpoint

    All patients are examined for FPG at endpoint. FPG are determined by the hexokinase method.

    Time frame: 6 months

  3. PPG at endpoint

    All patients are examined for PPG at endpoint. PPG are determined by the hexokinase method.

    Time frame: 6 months

  4. HbA1c at endpoint

    All patients are examined for HbA1c at endpoint. HbA1c are determined by high performance liquid chromatography.

    Time frame: 6 months

06

Study locations

No study locations are listed for this record.

07

Registry details

Key details

Study ID
NCT03252080
Lead sponsor
Cheng Qing-feng
Responsible party
Cheng Qing-feng (Associate professor, Chongqing Medical University) — Sponsor-investigator
First posted
Aug 17, 2017
Start date
Aug 2017 (estimated)
Primary completion
Mar 2018 (estimated)
Completion
Jul 2018 (estimated)
Last update
Aug 17, 2017

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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