An observational study in Invasive Breast Cancer, sponsored by Peking University. Completed at 1 site in China. Open to female participants. Per ClinicalTrials.gov, last updated 2019-09-06.
Sponsored by Peking University · Observational
This is a prospective, single-center, non-randomized, non-controlled observational study.
The negative predictive value of ultrasound for lymph node with neoadjuvant chemotherapy is low, magnetic resonance imaging (MRI) or PET/CT did not significantly improve specificity to axillary lymph node. The aim of this study is to determine performance of computed tomography (CT) reconstruction on evaluation of lymph node status after neoadjuvant chemotherapy in breast cancer patients.
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's enrollment of 160 is below the median of 184 across 2,642 observational studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Peking University is the lead sponsor of 411 studies on the registry; 122 are open to participants now.
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Invasive breast cancer with axillary lymph node metastasis: stage N1-2.
Exclusion Criteria:
Patients with invasive breast cancer who underwent computed tomography (CT) reconstruction of axillary lymph node for assessment of lymph node response after NAC are eligible for this study. Axillary lymph node metastasis is confirmed by fine needle aspiration (FNA) or core needle biopsy (CNB) at initial diagnosis.
Sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) of Computed tomography (CT) reconstruction for axillary lymph node status after neoadjuvant chemotherapy.
Sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) of Computed tomography (CT) reconstruction for axillary lymph node status after neoadjuvant chemotherapy will be assessed.
Time frame: within 6 weeks after obtaining the post-surgery pathological results
Rreceiver operating characteristic (ROC) curve analysis
The diagnostic performance of computed tomography (CT) reconstruction for the evaluation of ALN after NAC was evaluated with receiver operating characteristic (ROC) curve analysis. The diagnostic accuracy was estimated by calculating the area under the ROC curve.
Time frame: within 6 weeks after obtaining the post-surgery pathological results
This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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Peking University