An interventional study of Electroencephalography (EEG) multi-sensor and Magnetoencephalography (MEG) in Healthy, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-03.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Basic science
Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.
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Inclusion Criteria MGPFco group:
Inclusion Criteria MGPFph group:
Exclusion Criteria:
Other: Electroencephalography (EEG) multi-sensor · Other: Magnetoencephalography (MEG) · Other: Behavioral Measures · Other: Reaction time measurement · Other: Assessment of physical performance · Other: Electrooculogram (EOG) · Other: Electromyogram (EMG) · Other: Electrocardiogram with 3 leads
Other: Electroencephalography (EEG) multi-sensor · Other: Magnetoencephalography (MEG) · Other: Behavioral Measures · Other: Reaction time measurement · Other: Assessment of physical performance · Other: Electrooculogram (EOG) · Other: Electromyogram (EMG) · Other: Electrocardiogram with 3 leads · Other: Electrodermogram (EDG) · Other: Consumption of O2 (VO2) · Other: Production of CO2 (VCO2)
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.
Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.
The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.
The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.
The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.
The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time.
Time frame: 7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG).
Time frame: 7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.
Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG)
Time frame: 7 hours
Refine (locate at the level of the cortex), the origin of these physiological markers
Several types of recordings, passive and non-invasive, will be realized: * Electrooculogram (EOG); * electromyography (EMG); * electrocardiogram (ECG); Systematically in "physical" experiments and for some "cognitive" experiments.
Time frame: 7 hours
Distinguish between different time scales of performance
Several types of recordings, passive and non-invasive, will be realized: * electrodermogram (EDG); * the consumption of O2 (VO2); * production of CO2 (VCO2). Only and systematically, in "physical" experiments.
Time frame: 7 hours
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon