An interventional study of Early Goal Directed Therapy and Ruijin Strategy in Sepsis, sponsored by Ruijin Hospital. Status unknown. Open to participants aged 8 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-07-12.
Sponsored by Ruijin Hospital · Not applicable, Interventional, and Treatment
To evaluate two different strategy of fluid resuscitation in sepsis patients
Early goal-directed fluid therapy (EGDT) had been regarded as an important fluid therapy strategy in early sepsis or septic shock patients. In recent years, several randomized control studies showed the EGDT therapy cannot make a better outcome in sepsis patients compared to the standard therapy. A strategy of controlled fluid resuscitation had showed good outcome in critical illness such as severe acute pancreatitis, major trauma. But many aspects of the so-called controlled fluid resuscitation remained controversial. In a previous study on severe acute pancreatitis, we described a bundle of controlled fluid resuscitation which had showed an ideal result with higher survival rate. So, we are going to use the bundle on sepsis patients, and to see if it can bring a better out come in sepsis patients compared to the EGDT strategy. This study aims to determine a better strategy of fluid resuscitation in sepsis patients
1,894 studies on the registry are indexed under Sepsis; 458 are open to participants now.
This study's planned enrollment of 550 is above the median of 105 across 893 interventional studies indexed under Sepsis.
Browse Sepsis studies →Ruijin Hospital is the lead sponsor of 635 studies on the registry; 359 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Early Goal Directed Therapy ：30ml/kg in the first bolus to have a CVP（central venous pressure） 8-12 mmHg and MAP（mean artery pressure ） 65-85 mm Hg,and urine output ≥0.5 ml/kg/h, ScvO2 ≤70%；If not, use noradrenaline，red blood cell transfusion if necessary.
Other: Early Goal Directed Therapy
Ruijin Strategy therapy：10\~5ml/kg/h，crystalloid vs colloid 2:1 resuscitation;using noradrenaline at the same time;red blood cell transfusion if necessary. target： fulfillment of two or more of four criteria:1. HR（heart rate） \<120 beats/min, 2.MAP 65-85 mm Hg, 3. urine output ≥1 ml/kg /h 4. HCT（hematocrit） 25%\~35%.
Other: Ruijin Strategy
EGDT therapy ：30ml/kg in the first bolus to have a CVP 8-12 mmHg and MAP 65-85 mm Hg,and urine output ≥0.5 ml/kg/h, ScvO2 ≤70%；If not, use noradrenine，red blood cell transfusion if necessary.
Also known as: EGDT therapy
Ruijin Strategy：10\~5ml/kg/h，crystalloid vs colloid 2:1 resuscitation;using noradrenaline at the same time;red blood cell transfusion if necessary. target： fulfillment of two or more of four criteria:1. HR \<120 beats/min, 2.MAP 65-85 mm Hg, 3. urine output ≥1 ml/kg /h 4. HCT 25%\~35%.
Also known as: controlled fluid therapy
Mortality
Mortality
Time frame: the 28th day from enrolled
Mortality
Mortality
Time frame: the 60th day from enrolled
No study locations are listed for this record.
Plan to share: No
This study is status unknown, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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Ruijin Hospital